GO Annotations Graph

• Symbol: Akr1b1
• Name: aldo-keto reductase family 1 member B
• ID: MGI:1353494

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISO	J:155856
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IBA	J:265628
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IMP	J:127129
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IDA	J:23037
Molecular Function	GO:0047655	allyl-alcohol dehydrogenase activity	IEA	J:72245
Molecular Function	GO:0018505	cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity	ISO	J:155856
Molecular Function	GO:0043795	glyceraldehyde oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0047939	L-glucuronate reductase activity	IMP	J:164548
Molecular Function	GO:0052650	NADP-retinol dehydrogenase activity	IEA	J:72245
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0001758	retinal dehydrogenase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:261433
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0042629	mast cell granule	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0033010	paranodal junction	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032838	plasma membrane bounded cell projection cytoplasm	ISO	J:155856
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	ISO	J:155856
Cellular Component	GO:0097454	Schwann cell microvillus	ISO	J:155856
Biological Process	GO:0071475	cellular hyperosmotic salinity response	ISO	J:164563
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0097238	cellular response to methylglyoxal	ISO	J:155856
Biological Process	GO:0044597	daunorubicin metabolic process	ISO	J:164563
Biological Process	GO:0044598	doxorubicin metabolic process	ISO	J:164563
Biological Process	GO:0002070	epithelial cell maturation	IMP	J:109442
Biological Process	GO:0046370	fructose biosynthetic process	IMP	J:261433
Biological Process	GO:0046370	fructose biosynthetic process	IMP	J:127129
Biological Process	GO:0072061	inner medullary collecting duct development	ISO	J:155856
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	IMP	J:164548
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0072205	metanephric collecting duct development	IMP	J:109442
Biological Process	GO:0005996	monosaccharide metabolic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:109442
Biological Process	GO:0042415	norepinephrine metabolic process	ISO	J:155856
Biological Process	GO:1901360	organic cyclic compound metabolic process	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0035809	regulation of urine volume	IDA	J:109442
Biological Process	GO:0035809	regulation of urine volume	IMP	J:109442
Biological Process	GO:0003091	renal water homeostasis	IMP	J:109442
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0009414	response to water deprivation	ISO	J:155856
Biological Process	GO:0001523	retinoid metabolic process	ISO	J:164563
Biological Process	GO:0006061	sorbitol biosynthetic process	ISO	J:155856
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:155856
Biological Process	GO:0001894	tissue homeostasis	ISO	J:155856