Map2k2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Map2k2
mitogen-activated protein kinase kinase 2
MGI:1346867

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:164563
Molecular Function	GO:0004708	MAP kinase kinase activity	ISO	J:155856
Molecular Function	GO:0004708	MAP kinase kinase activity	IBA	J:265628
Molecular Function	GO:0004708	MAP kinase kinase activity	IDA	J:21571
Molecular Function	GO:0005078	MAP-kinase scaffold activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0060090	molecular adaptor activity	IDA	J:175345
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:175345
Molecular Function	GO:0005515	protein binding	IPI	J:175345
Molecular Function	GO:0005515	protein binding	IPI	J:200411
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	IDA	J:21571
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	TAS	J:180564
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:204095
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	J:180564
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005769	early endosome	TAS	J:180564
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	TAS	J:180564
Cellular Component	GO:0005794	Golgi apparatus	TAS	J:180564
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005770	late endosome	TAS	J:180564
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	TAS	J:180564
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	TAS	J:180564
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	IGI	J:214083
Biological Process	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	IGI	J:214083
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:214083
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:214083
Biological Process	GO:0060324	face development	IGI	J:144862
Biological Process	GO:0007507	heart development	IGI	J:144862
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:327220
Biological Process	GO:0060425	lung morphogenesis	IGI	J:214083
Biological Process	GO:0000165	MAPK cascade	IBA	J:265628
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:213126
Biological Process	GO:0050772	positive regulation of axonogenesis	IGI	J:213126
Biological Process	GO:2000147	positive regulation of cell motility	IDA	J:175345
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IGI	J:143745
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:213126
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:213126
Biological Process	GO:2000641	regulation of early endosome to late endosome transport	TAS	J:180564
Biological Process	GO:0090170	regulation of Golgi inheritance	TAS	J:180564
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	TAS	J:180564
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0048538	thymus development	IGI	J:144862
Biological Process	GO:0030878	thyroid gland development	IGI	J:144862
Biological Process	GO:0060440	trachea formation	IGI	J:214083

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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