GO Annotations Graph

• Symbol: Adcy8
• Name: adenylate cyclase 8
• ID: MGI:1341110

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0004016	adenylate cyclase activity	IBA	J:265628
Molecular Function	GO:0004016	adenylate cyclase activity	IMP	J:62135
Molecular Function	GO:0004016	adenylate cyclase activity	IMP	J:62135
Molecular Function	GO:0004016	adenylate cyclase activity	IMP	J:62135
Molecular Function	GO:0004016	adenylate cyclase activity	IGI	J:57343
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	IMP	J:63173
Molecular Function	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:62135
Molecular Function	GO:0140678	molecular function inhibitor activity	IMP	J:62135
Molecular Function	GO:0140678	molecular function inhibitor activity	IMP	J:62135
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:155856
Molecular Function	GO:0016849	phosphorus-oxygen lyase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:266119
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:155856
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:86425
Cellular Component	GO:0030424	axon	IDA	J:86425
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:86425
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	IDA	J:86425
Cellular Component	GO:0030425	dendrite	IDA	J:122007
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0060076	excitatory synapse	IDA	J:86425
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:86425
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:86425
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:57343
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:57343
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:86425
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IMP	J:86425
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0032809	neuronal cell body membrane	IDA	J:86425
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:331261
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:122007
Cellular Component	GO:0048786	presynaptic active zone	IDA	J:122007
Cellular Component	GO:0048786	presynaptic active zone	IDA	J:134966
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:122007
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:122007
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:122007
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:57343
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:57343
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0034199	activation of protein kinase A activity	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:220774
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:328576
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:220774
Biological Process	GO:0006171	cAMP biosynthetic process	ISO	J:155856
Biological Process	GO:0006171	cAMP biosynthetic process	IBA	J:265628
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:155856
Biological Process	GO:1904322	cellular response to forskolin	ISO	J:155856
Biological Process	GO:0071377	cellular response to glucagon stimulus	ISO	J:155856
Biological Process	GO:0071377	cellular response to glucagon stimulus	IDA	J:331261
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0071315	cellular response to morphine	ISO	J:155856
Biological Process	GO:0071315	cellular response to morphine	IMP	J:139609
Biological Process	GO:0009190	cyclic nucleotide biosynthetic process	IEA	J:72247
Biological Process	GO:0038003	G protein-coupled opioid receptor signaling pathway	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	IMP	J:220774
Biological Process	GO:0010255	glucose mediated signaling pathway	ISO	J:155856
Biological Process	GO:0010255	glucose mediated signaling pathway	IMP	J:220774
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0007626	locomotory behavior	IMP	J:139609
Biological Process	GO:0007616	long-term memory	IGI	J:57343
Biological Process	GO:0007613	memory	IMP	J:134966
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:86425
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:86425
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:86425
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:86425
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:57343
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:57343
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:57343
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:57343
Biological Process	GO:0150076	neuroinflammatory response	IMP	J:107678
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	IMP	J:63173
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	IMP	J:107678
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:220774
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:220774
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:328576
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:220774
Biological Process	GO:1900454	positive regulation of long-term synaptic depression	IMP	J:63173
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	IMP	J:57343
Biological Process	GO:0031915	positive regulation of synaptic plasticity	IMP	J:86425
Biological Process	GO:0051259	protein complex oligomerization	ISO	J:155856
Biological Process	GO:0051260	protein homooligomerization	ISO	J:155856
Biological Process	GO:0080135	regulation of cellular response to stress	IMP	J:266106
Biological Process	GO:0080135	regulation of cellular response to stress	IMP	J:127836
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	IMP	J:220774