GO Annotations Graph

• Symbol: Pak2
• Name: p21 (RAC1) activated kinase 2
• ID: MGI:1339984

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:140161
Molecular Function	GO:0005515	protein binding	IPI	J:145963
Molecular Function	GO:0004672	protein kinase activity	IDA	J:194236
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISS	J:55429
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:75789
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:243667
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:90763
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:90763
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IEP	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0014069	postsynaptic density	IDA	J:90763
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Biological Process	GO:0034333	adherens junction assembly	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0070830	bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:194236
Biological Process	GO:0060996	dendritic spine development	IGI	J:194236
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	ISO	J:164563
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:75789
Biological Process	GO:0150105	protein localization to cell-cell junction	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	ISO	J:75789
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0050770	regulation of axonogenesis	IBA	J:265628
Biological Process	GO:0051493	regulation of cytoskeleton organization	ISO	J:164563
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0043408	regulation of MAPK cascade	IBA	J:265628