GO Annotations Graph

• Symbol: Tnfrsf11a
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
• ID: MGI:1314891

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:245342
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:245306
Molecular Function	GO:0005515	protein binding	IPI	J:54076
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IMP	J:155398
Molecular Function	GO:0005031	tumor necrosis factor receptor activity	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:177783
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	ISO	J:164563
Biological Process	GO:0060086	circadian temperature homeostasis	IMP	J:155398
Biological Process	GO:0048535	lymph node development	IBA	J:265628
Biological Process	GO:0048535	lymph node development	IMP	J:57899
Biological Process	GO:0060749	mammary gland alveolus development	IBA	J:265628
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:64718
Biological Process	GO:0007275	multicellular organism development	IMP	J:57899
Biological Process	GO:0072674	multinuclear osteoclast differentiation	IBA	J:265628
Biological Process	GO:0072674	multinuclear osteoclast differentiation	IMP	J:76221
Biological Process	GO:0001503	ossification	IBA	J:265628
Biological Process	GO:0001503	ossification	IMP	J:57899
Biological Process	GO:0030316	osteoclast differentiation	ISO	J:164563
Biological Process	GO:0045780	positive regulation of bone resorption	IBA	J:265628
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:76221
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:155398
Biological Process	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	ISO	J:164563
Biological Process	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	IMP	J:155398
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0034097	response to cytokine	ISO	J:164563
Biological Process	GO:0070555	response to interleukin-1	IMP	J:155398
Biological Process	GO:0070555	response to interleukin-1	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:155398
Biological Process	GO:0034612	response to tumor necrosis factor	IMP	J:155398
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IMP	J:155398