GO Annotations Graph

• Symbol: Rgs2
• Name: regulator of G-protein signaling 2
• ID: MGI:1098271

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010855	adenylate cyclase inhibitor activity	IMP	J:167211
Molecular Function	GO:0048487	beta-tubulin binding	ISO	J:155856
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	TAS	J:69278
Molecular Function	GO:0005515	protein binding	IPI	J:235324
Molecular Function	GO:0005515	protein binding	IPI	J:154724
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:172850
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IMP	J:146192
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	TAS	J:69278
Cellular Component	GO:0005886	plasma membrane	IMP	J:146192
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0050873	brown fat cell differentiation	IDA	J:137608
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	TAS	J:69278
Biological Process	GO:0140194	negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process	IMP	J:172850
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	IMP	J:146192
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	IMP	J:146192
Biological Process	GO:1900924	negative regulation of glycine import across plasma membrane	ISO	J:155856
Biological Process	GO:0043407	negative regulation of MAP kinase activity	IMP	J:146192
Biological Process	GO:0010519	negative regulation of phospholipase activity	IMP	J:146192
Biological Process	GO:0009968	negative regulation of signal transduction	IEA	J:60000
Biological Process	GO:0017148	negative regulation of translation	ISO	J:155856
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	IMP	J:172850
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	IMP	J:146192
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0055119	relaxation of cardiac muscle	IMP	J:146192
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	IMP	J:86774
Biological Process	GO:0007283	spermatogenesis	IEP	J:86344