GO Annotations Graph

• Symbol: Rhoa
• Name: ras homolog family member A
• ID: MGI:1096342

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003925	G protein activity	IEA	J:72245
Molecular Function	GO:0019003	GDP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	ISO	J:155856
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	ISO	J:241798
Molecular Function	GO:0003924	GTPase activity	TAS	J:52995
Molecular Function	GO:0003924	GTPase activity	IDA	J:80946
Molecular Function	GO:0003924	GTPase activity	IDA	J:91862
Molecular Function	GO:0003924	GTPase activity	IDA	J:97653
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0017022	myosin binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:234083
Molecular Function	GO:0005515	protein binding	IPI	J:169711
Molecular Function	GO:0005515	protein binding	IPI	J:209645
Molecular Function	GO:0005515	protein binding	IPI	J:240585
Molecular Function	GO:0005515	protein binding	IPI	J:143595
Molecular Function	GO:0005515	protein binding	IPI	J:167914
Molecular Function	GO:0005515	protein binding	IPI	J:159310
Molecular Function	GO:0005515	protein binding	IPI	J:134634
Molecular Function	GO:0005515	protein binding	IPI	J:176254
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0005515	protein binding	IPI	J:41124
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0051022	Rho GDP-dissociation inhibitor binding	ISO	J:155856
Cellular Component	GO:0043296	apical junction complex	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0032154	cleavage furrow	ISO	J:164563
Cellular Component	GO:0032154	cleavage furrow	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:75088
Cellular Component	GO:0005829	cytosol	TAS	J:52995
Cellular Component	GO:0043197	dendritic spine	ISO	J:164563
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:200496
Cellular Component	GO:0030027	lamellipodium	IDA	J:144247
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005634	nucleus	IDA	J:89351
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5625893
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5666183
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5667058
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8981447
Cellular Component	GO:0005886	plasma membrane	IDA	J:89351
Cellular Component	GO:0098794	postsynapse	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IDA	J:41124
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IDA	J:87888
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0002363	alpha-beta T cell lineage commitment	IMP	J:221513
Biological Process	GO:0030521	androgen receptor signaling pathway	IDA	J:105872
Biological Process	GO:0001998	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IMP	J:221301
Biological Process	GO:0003189	aortic valve formation	ISO	J:164563
Biological Process	GO:0043297	apical junction assembly	IDA	J:169711
Biological Process	GO:0043297	apical junction assembly	ISO	J:164563
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0043366	beta selection	IMP	J:221513
Biological Process	GO:0007155	cell adhesion	IMP	J:87902
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IDA	J:75088
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0034329	cell junction assembly	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0000902	cell morphogenesis	IGI	J:98043
Biological Process	GO:0007160	cell-matrix adhesion	IDA	J:87888
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:164563
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0021795	cerebral cortex cell migration	IMP	J:182669
Biological Process	GO:0036089	cleavage furrow formation	ISO	J:164563
Biological Process	GO:0031122	cytoplasmic microtubule organization	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	IMP	J:182669
Biological Process	GO:0043542	endothelial cell migration	ISO	J:168264
Biological Process	GO:0097498	endothelial tube lumen extension	ISO	J:168264
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0021861	forebrain radial glial cell differentiation	IMP	J:182669
Biological Process	GO:0046039	GTP metabolic process	ISO	J:155856
Biological Process	GO:0007229	integrin-mediated signaling pathway	TAS	J:52995
Biological Process	GO:0001822	kidney development	IGI	J:276466
Biological Process	GO:1903673	mitotic cleavage furrow formation	ISO	J:164563
Biological Process	GO:0090307	mitotic spindle assembly	ISO	J:164563
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:100207
Biological Process	GO:0050919	negative chemotaxis	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:168264
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:164563
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	IMP	J:247468
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	IDA	J:105872
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:100207
Biological Process	GO:0045665	negative regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	IMP	J:221513
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	IMP	J:221513
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	ISO	J:281765
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:281765
Biological Process	GO:0001764	neuron migration	IMP	J:182669
Biological Process	GO:0042476	odontogenesis	IEP	J:224690
Biological Process	GO:0043931	ossification involved in bone maturation	IMP	J:178104
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation	IMP	J:221513
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	ISO	J:164563
Biological Process	GO:0060193	positive regulation of lipase activity	ISO	J:164563
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:117491
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:117491
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0071803	positive regulation of podosome assembly	IGI	J:182942
Biological Process	GO:0071803	positive regulation of podosome assembly	IGI	J:182942
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:93907
Biological Process	GO:0051496	positive regulation of stress fiber assembly	IDA	J:276466
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:164563
Biological Process	GO:1904695	positive regulation of vascular associated smooth muscle contraction	IMP	J:221301
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IMP	J:221513
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:0050773	regulation of dendrite development	ISO	J:155856
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	IMP	J:221513
Biological Process	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	ISO	J:164563
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	ISO	J:164563
Biological Process	GO:1905244	regulation of modification of synaptic structure	ISO	J:155856
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	IMP	J:182669
Biological Process	GO:0010975	regulation of neuron projection development	IDA	J:177108
Biological Process	GO:0033688	regulation of osteoblast proliferation	IMP	J:178104
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	IMP	J:221301
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:136004
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:155856
Biological Process	GO:0007266	Rho protein signal transduction	TAS	J:52995
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:281765
Biological Process	GO:0035385	Roundabout signaling pathway	ISO	J:164563
Biological Process	GO:0007519	skeletal muscle tissue development	IDA	J:75088
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0043149	stress fiber assembly	ISO	J:164563
Biological Process	GO:0043149	stress fiber assembly	IBA	J:265628
Biological Process	GO:0043149	stress fiber assembly	IDA	J:87748
Biological Process	GO:0043149	stress fiber assembly	IDA	J:80946
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	ISO	J:155856
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0061383	trabecula morphogenesis	IMP	J:178104