GO Annotations Graph

• Symbol: Axin1
• Name: axin 1
• ID: MGI:1096327

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070016	armadillo repeat domain binding	ISO	J:155856
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	IBA	J:265628
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:54993
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:141207
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:55044
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IDA	J:109361
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0070411	I-SMAD binding	IPI	J:109361
Molecular Function	GO:0070411	I-SMAD binding	IPI	J:109361
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:53684
Molecular Function	GO:0042802	identical protein binding	IPI	J:54993
Molecular Function	GO:0042802	identical protein binding	IPI	J:96879
Molecular Function	GO:0042802	identical protein binding	IPI	J:141207
Molecular Function	GO:0060090	molecular adaptor activity	IMP	J:109361
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	IBA	J:265628
Molecular Function	GO:0002039	p53 binding	IPI	J:94782
Molecular Function	GO:0005515	protein binding	IPI	J:166025
Molecular Function	GO:0005515	protein binding	IPI	J:181909
Molecular Function	GO:0005515	protein binding	IPI	J:162153
Molecular Function	GO:0005515	protein binding	IPI	J:180542
Molecular Function	GO:0005515	protein binding	IPI	J:166010
Molecular Function	GO:0005515	protein binding	IPI	J:169940
Molecular Function	GO:0005515	protein binding	IPI	J:220301
Molecular Function	GO:0005515	protein binding	IPI	J:187517
Molecular Function	GO:0005515	protein binding	IPI	J:83951
Molecular Function	GO:0005515	protein binding	IPI	J:178440
Molecular Function	GO:0005515	protein binding	IPI	J:214515
Molecular Function	GO:0005515	protein binding	IPI	J:201942
Molecular Function	GO:0005515	protein binding	IPI	J:182380
Molecular Function	GO:0005515	protein binding	IPI	J:118821
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0005515	protein binding	IPI	J:162096
Molecular Function	GO:0005515	protein binding	IPI	J:212813
Molecular Function	GO:0005515	protein binding	IPI	J:67543
Molecular Function	GO:0005515	protein binding	IPI	J:110693
Molecular Function	GO:0005515	protein binding	IPI	J:85664
Molecular Function	GO:0005515	protein binding	IPI	J:85664
Molecular Function	GO:0005515	protein binding	IPI	J:137475
Molecular Function	GO:0005515	protein binding	IPI	J:92506
Molecular Function	GO:0005515	protein binding	IDA	J:54993
Molecular Function	GO:0005515	protein binding	IPI	J:96879
Molecular Function	GO:0005515	protein binding	IPI	J:137475
Molecular Function	GO:0005515	protein binding	IPI	J:137475
Molecular Function	GO:0005515	protein binding	IPI	J:145745
Molecular Function	GO:0005515	protein binding	IPI	J:53684
Molecular Function	GO:0005515	protein binding	IPI	J:96879
Molecular Function	GO:0005515	protein binding	IPI	J:141207
Molecular Function	GO:0005515	protein binding	IPI	J:141207
Molecular Function	GO:0005515	protein binding	IPI	J:148434
Molecular Function	GO:0005515	protein binding	IPI	J:137475
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:96879
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:137475
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:137475
Molecular Function	GO:0019901	protein kinase binding	IPI	J:188340
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0019901	protein kinase binding	IPI	J:54993
Molecular Function	GO:0019901	protein kinase binding	IPI	J:94782
Molecular Function	GO:0043621	protein self-association	IPI	J:96879
Molecular Function	GO:0070412	R-SMAD binding	IPI	J:109361
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:109361
Cellular Component	GO:0030877	beta-catenin destruction complex	TAS	J:228120
Cellular Component	GO:0030877	beta-catenin destruction complex	NAS	J:319997
Cellular Component	GO:0030877	beta-catenin destruction complex	ISO	J:155856
Cellular Component	GO:0030877	beta-catenin destruction complex	ISO	J:164563
Cellular Component	GO:0030877	beta-catenin destruction complex	IBA	J:265628
Cellular Component	GO:0030877	beta-catenin destruction complex	IDA	J:54993
Cellular Component	GO:0005938	cell cortex	IDA	J:55044
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:109361
Cellular Component	GO:0005737	cytoplasm	IDA	J:137474
Cellular Component	GO:0005737	cytoplasm	IDA	J:67543
Cellular Component	GO:0005737	cytoplasm	ISO	J:55044
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:67543
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-209059
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-209096
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-209148
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-209146
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016328	lateral plasma membrane	ISO	J:73065
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:87882
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:236219
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:110693
Cellular Component	GO:0005886	plasma membrane	NAS	J:162153
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:55044
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:109361
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:1990909	Wnt signalosome	IDA	J:188340
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0007628	adult walking behavior	IMP	MGI:MGI:48782
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0048318	axial mesoderm development	IMP	J:41619
Biological Process	GO:0048320	axial mesoderm formation	IMP	J:41619
Biological Process	GO:0060070	canonical Wnt signaling pathway	IMP	J:145745
Biological Process	GO:0060070	canonical Wnt signaling pathway	IDA	J:125420
Biological Process	GO:0048468	cell development	IBA	J:265628
Biological Process	GO:0031122	cytoplasmic microtubule organization	IGI	J:87882
Biological Process	GO:0009950	dorsal/ventral axis specification	IDA	J:55044
Biological Process	GO:0009950	dorsal/ventral axis specification	ISO	J:137475
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:137089
Biological Process	GO:0009953	dorsal/ventral pattern formation	ISO	J:137475
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	IMP	MGI:MGI:48782
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	IMP	MGI:MGI:48782
Biological Process	GO:0034101	erythrocyte homeostasis	IMP	MGI:MGI:48782
Biological Process	GO:0071514	genomic imprinting	IMP	J:82396
Biological Process	GO:0060322	head development	IMP	J:169694
Biological Process	GO:0020027	hemoglobin metabolic process	IMP	MGI:MGI:48782
Biological Process	GO:0001701	in utero embryonic development	IGI	J:147293
Biological Process	GO:0001701	in utero embryonic development	IMP	J:147293
Biological Process	GO:0001701	in utero embryonic development	IMP	J:147293
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:147293
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:96879
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IDA	J:125420
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:138264
Biological Process	GO:0051248	negative regulation of protein metabolic process	IDA	J:55044
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IDA	J:147293
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IDA	J:54993
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:137475
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:41619
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:83550
Biological Process	GO:0050877	nervous system process	IMP	MGI:MGI:48782
Biological Process	GO:0006913	nucleocytoplasmic transport	IDA	J:88659
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:109361
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:137475
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:137089
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:96879
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:137475
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IDA	J:85664
Biological Process	GO:0043507	positive regulation of JUN kinase activity	IMP	J:85664
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:228120
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	IDA	J:228120
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	J:109361
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	IDA	J:94782
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IBA	J:265628
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:55044
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IGI	J:109361
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:109361
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:109361
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	J:109361
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IGI	J:109361
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IDA	J:109361
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	ISO	J:155856
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IDA	J:109361
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	IMP	J:109361
Biological Process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	MGI:MGI:48782
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	MGI:MGI:48782
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	J:82396
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	NAS	J:319997
Biological Process	GO:0030163	protein catabolic process	IDA	J:83550
Biological Process	GO:0000209	protein polyubiquitination	IDA	J:109361
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	IDA	J:88659
Biological Process	GO:0001932	regulation of protein phosphorylation	IGI	J:87882
Biological Process	GO:0007605	sensory perception of sound	IMP	J:242
Biological Process	GO:0007605	sensory perception of sound	IMP	MGI:MGI:48782
Biological Process	GO:0016055	Wnt signaling pathway	IPI	J:67543
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:67543