GO Annotations Graph

• Symbol: Pten
• Name: phosphatase and tensin homolog
• ID: MGI:109583

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010997	anaphase-promoting complex binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	ISO	J:164563
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0017018	myosin phosphatase activity	IEA	J:72245
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	ISO	J:155856
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	ISO	J:164563
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA	J:265628
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IDA	J:77008
Molecular Function	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	ISO	J:164563
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	ISO	J:164563
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	ISO	J:164563
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:191729
Molecular Function	GO:0005515	protein binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:227354
Molecular Function	GO:0005515	protein binding	IPI	J:141030
Molecular Function	GO:0005515	protein binding	IPI	J:105981
Molecular Function	GO:0005515	protein binding	IPI	J:120364
Molecular Function	GO:0005515	protein binding	IPI	J:169887
Molecular Function	GO:0005515	protein binding	IPI	J:136033
Molecular Function	GO:0005515	protein binding	IPI	J:160700
Molecular Function	GO:0019901	protein kinase binding	IPI	J:178436
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:1990381	ubiquitin-specific protease binding	ISO	J:227354
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0042995	cell projection	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:93902
Cellular Component	GO:0005737	cytoplasm	IDA	J:137202
Cellular Component	GO:0005737	cytoplasm	IDA	J:93902
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0035749	myelin sheath adaxonal region	IDA	J:159103
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IMP	J:175650
Cellular Component	GO:0043005	neuron projection	IDA	J:175650
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:93902
Cellular Component	GO:0005634	nucleus	IDA	J:136033
Cellular Component	GO:0005634	nucleus	IDA	J:137202
Cellular Component	GO:0005634	nucleus	IDA	J:93902
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	IDA	J:159103
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0030534	adult behavior	IMP	J:109635
Biological Process	GO:0001525	angiogenesis	IMP	J:100493
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0042100	B cell proliferation	IMP	J:100095
Biological Process	GO:0048854	brain morphogenesis	IMP	J:144937
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0048738	cardiac muscle tissue development	IMP	J:100493
Biological Process	GO:0016477	cell migration	IMP	J:77123
Biological Process	GO:0048870	cell motility	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IMP	J:100095
Biological Process	GO:0008283	cell population proliferation	IGI	J:100094
Biological Process	GO:0036294	cellular response to decreased oxygen levels	IDA	J:213269
Biological Process	GO:0071257	cellular response to electrical stimulus	ISO	J:164563
Biological Process	GO:0071361	cellular response to ethanol	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	IDA	J:213269
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	ISO	J:155856
Biological Process	GO:0044320	cellular response to leptin stimulus	ISO	J:155856
Biological Process	GO:0007417	central nervous system development	IMP	J:77123
Biological Process	GO:0032286	central nervous system myelin maintenance	IMP	J:130843
Biological Process	GO:0021955	central nervous system neuron axonogenesis	IMP	J:109635
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:130843
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:184118
Biological Process	GO:0021542	dentate gyrus development	IMP	J:125726
Biological Process	GO:0016311	dephosphorylation	IEA	J:72247
Biological Process	GO:0043542	endothelial cell migration	IMP	J:100493
Biological Process	GO:0048853	forebrain morphogenesis	IMP	J:109635
Biological Process	GO:0007507	heart development	IMP	J:98216
Biological Process	GO:0071545	inositol phosphate catabolic process	ISO	J:155856
Biological Process	GO:0007611	learning or memory	IMP	J:109635
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0045475	locomotor rhythm	IMP	J:125726
Biological Process	GO:0007626	locomotory behavior	IMP	J:109635
Biological Process	GO:0060292	long-term synaptic depression	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:130843
Biological Process	GO:0060179	male mating behavior	IMP	J:109635
Biological Process	GO:0042711	maternal behavior	IMP	J:109635
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0033555	multicellular organismal response to stress	IMP	J:109635
Biological Process	GO:0042552	myelination	IMP	J:160700
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:71874
Biological Process	GO:0048681	negative regulation of axon regeneration	IMP	J:225812
Biological Process	GO:0050771	negative regulation of axonogenesis	IMP	J:109635
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:100095
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	ISO	J:155856
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	IGI	J:213298
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:155856
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:100094
Biological Process	GO:0045792	negative regulation of cell size	IMP	J:184118
Biological Process	GO:0045792	negative regulation of cell size	IMP	J:109635
Biological Process	GO:2000773	negative regulation of cellular senescence	IMP	J:173135
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:1900425	negative regulation of defense response to bacterium	ISO	J:155856
Biological Process	GO:1903860	negative regulation of dendrite extension	ISO	J:155856
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	IMP	J:109635
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:99524
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	IMP	J:184118
Biological Process	GO:1905450	negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	ISO	J:155856
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0051548	negative regulation of keratinocyte migration	ISO	J:164563
Biological Process	GO:0031642	negative regulation of myelination	IMP	J:160700
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0046621	negative regulation of organ growth	IMP	J:144937
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	ISO	J:155856
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:109635
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:71874
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:227354
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:216935
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IMP	J:160700
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:225488
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0090071	negative regulation of ribosome biogenesis	IMP	J:130843
Biological Process	GO:2000272	negative regulation of signaling receptor activity	ISO	J:155856
Biological Process	GO:2000808	negative regulation of synaptic vesicle clustering	IMP	J:109635
Biological Process	GO:2000808	negative regulation of synaptic vesicle clustering	IMP	J:130843
Biological Process	GO:0042130	negative regulation of T cell proliferation	IMP	J:100095
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:1903690	negative regulation of wound healing, spreading of epidermal cells	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0007270	neuron-neuron synaptic transmission	IMP	J:130843
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	ISO	J:155856
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	ISO	J:164563
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	IBA	J:265628
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IMP	J:77008
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:173135
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:216935
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:130843
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity	ISO	J:164563
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity	IMP	J:173135
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0097107	postsynaptic density assembly	IMP	J:130843
Biological Process	GO:0060134	prepulse inhibition	IMP	J:109635
Biological Process	GO:0060134	prepulse inhibition	IMP	J:144937
Biological Process	GO:0097105	presynaptic membrane assembly	IMP	J:130843
Biological Process	GO:0060736	prostate gland growth	IMP	J:99524
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:155856
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	IBA	J:265628
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:178436
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:225488
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:216935
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:160700
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:160700
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0048679	regulation of axon regeneration	IGI	J:213126
Biological Process	GO:0002902	regulation of B cell apoptotic process	IMP	J:53065
Biological Process	GO:0051726	regulation of cell cycle	IGI	J:136033
Biological Process	GO:0032535	regulation of cellular component size	IMP	J:130843
Biological Process	GO:0060341	regulation of cellular localization	IMP	J:170129
Biological Process	GO:2000109	regulation of macrophage apoptotic process	IMP	J:53065
Biological Process	GO:0010975	regulation of neuron projection development	IMP	J:154919
Biological Process	GO:0051896	regulation of protein kinase B signaling	IBA	J:265628
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	IMP	J:213269
Biological Process	GO:0060024	rhythmic synaptic transmission	IMP	J:125726
Biological Process	GO:0035176	social behavior	IMP	J:144937
Biological Process	GO:0035176	social behavior	IMP	J:109635
Biological Process	GO:0007416	synapse assembly	IMP	J:109635
Biological Process	GO:0060074	synapse maturation	IMP	J:130843
Biological Process	GO:0042098	T cell proliferation	IMP	J:100095