GO Annotations Graph

• Symbol: Dnm2
• Name: dynamin 2
• ID: MGI:109547

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031749	D2 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0005525	GTP binding	IEA	J:72247
Molecular Function	GO:0003924	GTPase activity	ISO	J:155856
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	IBA	J:265628
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:222139
Molecular Function	GO:0005515	protein binding	IPI	J:190005
Molecular Function	GO:0005515	protein binding	IPI	J:73611
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0120283	protein serine/threonine kinase binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0050699	WW domain binding	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:155856
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:227201
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005874	microtubule	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0001891	phagocytic cup	ISO	J:155856
Cellular Component	GO:0001917	photoreceptor inner segment	IDA	J:214070
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:164563
Cellular Component	GO:0098793	presynapse	IDA	J:175247
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032587	ruffle membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IDA	J:175247
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:155856
Biological Process	GO:0060976	coronary vasculature development	IMP	J:222159
Biological Process	GO:0006897	endocytosis	ISO	J:164563
Biological Process	GO:0002031	G protein-coupled receptor internalization	ISO	J:155856
Biological Process	GO:0006893	Golgi to plasma membrane transport	ISO	J:155856
Biological Process	GO:0044351	macropinocytosis	ISO	J:155856
Biological Process	GO:1903526	negative regulation of membrane tubulation	ISO	J:164563
Biological Process	GO:1902856	negative regulation of non-motile cilium assembly	ISO	J:155856
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	ISO	J:155856
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:1903408	positive regulation of P-type sodium:potassium-exchanging transporter activity	ISO	J:155856
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:155856
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:155856
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0030516	regulation of axon extension	ISO	J:155856
Biological Process	GO:1903358	regulation of Golgi organization	ISO	J:155856
Biological Process	GO:0035020	regulation of Rac protein signal transduction	ISO	J:155856
Biological Process	GO:0048488	synaptic vesicle endocytosis	IBA	J:265628
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:175247
Biological Process	GO:0048488	synaptic vesicle endocytosis	IDA	J:175247
Biological Process	GO:0048488	synaptic vesicle endocytosis	IMP	J:175247
Biological Process	GO:0033572	transferrin transport	ISO	J:164563
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159