GO Annotations Graph

• Symbol: Epas1
• Name: endothelial PAS domain protein 1
• ID: MGI:109169

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:82142
Molecular Function	GO:0050897	cobalt ion binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:121253
Molecular Function	GO:0003677	DNA binding	ISO	J:73065
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180719
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:82142
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:203396
Molecular Function	GO:0005515	protein binding	IPI	J:41526
Molecular Function	GO:0005515	protein binding	IPI	J:247431
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:247431
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	J:41526
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:247431
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:82142
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:84384
Cellular Component	GO:0016607	nuclear speck	IDA	J:203396
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:203396
Cellular Component	GO:0005634	nucleus	IDA	J:82142
Cellular Component	GO:0005634	nucleus	IDA	J:82142
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:73065
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:73065
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:82142
Biological Process	GO:0001525	angiogenesis	IMP	J:100440
Biological Process	GO:0001525	angiogenesis	IMP	J:96396
Biological Process	GO:0001525	angiogenesis	IMP	J:77480
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:63415
Biological Process	GO:0030154	cell differentiation	IGI	J:119854
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	IBA	J:265628
Biological Process	GO:0001892	embryonic placenta development	IGI	J:119854
Biological Process	GO:0002070	epithelial cell maturation	IMP	J:77480
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:119731
Biological Process	GO:0010467	gene expression	IMP	J:152650
Biological Process	GO:0010467	gene expression	IMP	J:230295
Biological Process	GO:0030097	hemopoiesis	IMP	J:85299
Biological Process	GO:0030097	hemopoiesis	IMP	J:98454
Biological Process	GO:0030324	lung development	IMP	J:77480
Biological Process	GO:0007005	mitochondrion organization	IMP	J:86736
Biological Process	GO:0007005	mitochondrion organization	IMP	J:86736
Biological Process	GO:0007005	mitochondrion organization	IMP	J:86736
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:152650
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IGI	J:181769
Biological Process	GO:0048625	myoblast fate commitment	IMP	J:167144
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0042421	norepinephrine biosynthetic process	ISO	J:155856
Biological Process	GO:0042415	norepinephrine metabolic process	IMP	J:50964
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:235908
Biological Process	GO:1903181	positive regulation of dopamine biosynthetic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:82142
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41526
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:82142
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:121138
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41526
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:121253
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0002027	regulation of heart rate	IMP	J:50964
Biological Process	GO:2000434	regulation of protein neddylation	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IDA	J:86736
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IDA	J:86736
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IDA	J:86736
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IMP	J:119731
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IDA	J:86736
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	IMP	J:230295
Biological Process	GO:0001666	response to hypoxia	ISO	J:75462
Biological Process	GO:0001666	response to hypoxia	IMP	J:98454
Biological Process	GO:0006979	response to oxidative stress	IMP	J:86736
Biological Process	GO:0006979	response to oxidative stress	IGI	J:121138
Biological Process	GO:0043129	surfactant homeostasis	IMP	J:77480
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:121253
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:121253
Biological Process	GO:0007601	visual perception	IMP	J:96396