Sfrp2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Sfrp2
secreted frizzled-related protein 2
MGI:108078

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0061133	endopeptidase activator activity	IDA	J:146963
Molecular Function	GO:0008047	enzyme activator activity	IDA	J:146963
Molecular Function	GO:0005515	protein binding	IPI	J:245307
Molecular Function	GO:0005515	protein binding	IPI	J:146963
Molecular Function	GO:0005515	protein binding	IPI	J:51287
Molecular Function	GO:0005515	protein binding	IPI	J:39275
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:165596
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:121773
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:121773
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-3772439
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:164792
Cellular Component	GO:0005615	extracellular space	IDA	J:164790
Cellular Component	GO:0005615	extracellular space	IDA	J:53153
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106551
Biological Process	GO:0006915	apoptotic process	IMP	J:138805
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:157031
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IDA	J:164762
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:157031
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0003214	cardiac left ventricle morphogenesis	ISO	J:164563
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	IDA	J:119489
Biological Process	GO:0051216	cartilage development	IMP	J:138805
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0031668	cellular response to extracellular stimulus	IDA	J:54434
Biological Process	GO:0071481	cellular response to X-ray	IDA	J:164747
Biological Process	GO:0002063	chondrocyte development	IMP	J:138805
Biological Process	GO:0030199	collagen fibril organization	IMP	J:146963
Biological Process	GO:0060028	convergent extension involved in axis elongation	IGI	J:135313
Biological Process	GO:0060028	convergent extension involved in axis elongation	IGI	J:135313
Biological Process	GO:0046546	development of primary male sexual characteristics	IGI	J:147206
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0042733	embryonic digit morphogenesis	IMP	J:138805
Biological Process	GO:0071425	hematopoietic stem cell proliferation	IDA	J:164747
Biological Process	GO:0008584	male gonad development	IGI	J:147206
Biological Process	GO:0007501	mesodermal cell fate specification	IGI	J:121773
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:157031
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:157031
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:124891
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:121773
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:157031
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IDA	J:119489
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	IDA	J:164790
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:119489
Biological Process	GO:0061185	negative regulation of dermatome development	IDA	J:53153
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:164792
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:164790
Biological Process	GO:0043508	negative regulation of JUN kinase activity	IGI	J:147041
Biological Process	GO:0043508	negative regulation of JUN kinase activity	IGI	J:147041
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	IGI	J:121773
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IDA	J:164790
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:227398
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:53153
Biological Process	GO:0001843	neural tube closure	IGI	J:157031
Biological Process	GO:0021915	neural tube development	IGI	J:157031
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	ISO	J:164563
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0045766	positive regulation of angiogenesis	IDA	J:164762
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	J:165596
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA	J:227384
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IGI	J:131066
Biological Process	GO:0030307	positive regulation of cell growth	IDA	J:164790
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:164790
Biological Process	GO:0010950	positive regulation of endopeptidase activity	IDA	J:146963
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:78619
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:131066
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IDA	J:165596
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:165596
Biological Process	GO:0036342	post-anal tail morphogenesis	IMP	J:138805
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:138805
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:138805
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	IGI	J:190506
Biological Process	GO:0010975	regulation of neuron projection development	IDA	J:190506
Biological Process	GO:2000035	regulation of stem cell division	IDA	J:164747
Biological Process	GO:0030111	regulation of Wnt signaling pathway	IDA	J:164792
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:164747
Biological Process	GO:0061056	sclerotome development	IEP	J:53153
Biological Process	GO:0001756	somitogenesis	IGI	J:106551
Biological Process	GO:0048866	stem cell fate specification	IGI	J:121773
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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