GO Annotations Graph

• Symbol: Laptm5
• Name: lysosomal-associated protein transmembrane 5
• ID: MGI:108046

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019899	enzyme binding	IPI	J:286941
Molecular Function	GO:0005515	protein binding	IPI	J:137841
Molecular Function	GO:0140311	protein sequestering activity	IMP	J:137841
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IBA	J:265628
Cellular Component	GO:0005764	lysosome	IDA	J:297527
Cellular Component	GO:0005764	lysosome	IDA	J:137841
Cellular Component	GO:0005764	lysosome	IDA	J:189244
Cellular Component	GO:0005764	lysosome	IDA	J:161622
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IDA	J:286941
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0030133	transport vesicle	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0002357	defense response to tumor cell	ISO	J:164563
Biological Process	GO:0090160	Golgi to lysosome transport	IDA	J:297527
Biological Process	GO:0012502	induction of programmed cell death	ISO	J:164563
Biological Process	GO:0006886	intracellular protein transport	IMP	J:298907
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	IMP	J:137841
Biological Process	GO:1904093	negative regulation of autophagic cell death	ISO	J:164563
Biological Process	GO:0050869	negative regulation of B cell activation	IMP	J:161622
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IMP	J:137841
Biological Process	GO:0140646	negative regulation of pre-B cell receptor expression	IMP	J:189244
Biological Process	GO:0050868	negative regulation of T cell activation	IMP	J:137841
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	IMP	J:137841
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:137841
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	IMP	J:286941
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:286941
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:286941
Biological Process	GO:0097214	positive regulation of lysosomal membrane permeability	ISO	J:164563
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:286941
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:286941
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:286941
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IMP	J:286941
Biological Process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	IMP	J:189244
Biological Process	GO:2000646	positive regulation of receptor catabolic process	IMP	J:161622
Biological Process	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:286941
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IDA	J:297527
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IMP	J:137841
Biological Process	GO:0061462	protein localization to lysosome	IMP	J:189244
Biological Process	GO:0006622	protein targeting to lysosome	IDA	J:137841