Myd88 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Myd88
myeloid differentiation primary response gene 88
MGI:108005

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140674	ATP-dependent histone chaperone activity	IMP	J:136566
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005149	interleukin-1 receptor binding	ISO	J:155856
Molecular Function	GO:0005149	interleukin-1 receptor binding	IDA	J:64697
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:143338
Molecular Function	GO:0005515	protein binding	IPI	J:211317
Molecular Function	GO:0005515	protein binding	IPI	J:266414
Molecular Function	GO:0005515	protein binding	IPI	J:188561
Molecular Function	GO:0005515	protein binding	IPI	J:110094
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:180126
Molecular Function	GO:0005515	protein binding	IPI	J:162535
Molecular Function	GO:0005515	protein binding	IPI	J:115304
Molecular Function	GO:0005515	protein binding	IPI	J:180054
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:107309
Molecular Function	GO:0005515	protein binding	IPI	J:64697
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0005515	protein binding	IPI	J:145929
Molecular Function	GO:0005515	protein binding	IPI	J:145929
Molecular Function	GO:0005515	protein binding	IPI	J:145929
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0005515	protein binding	IPI	J:71392
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0070976	TIR domain binding	ISO	J:164563
Molecular Function	GO:0005121	Toll binding	ISO	J:155856
Molecular Function	GO:0035325	Toll-like receptor binding	IPI	J:231858
Molecular Function	GO:0035325	Toll-like receptor binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	TAS	J:57233
Cellular Component	GO:0005829	cytosol	IDA	J:171185
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0019897	extrinsic component of plasma membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:171185
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:89998
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:277857
Biological Process	GO:0071310	cellular response to organic substance	IMP	J:277730
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	IMP	J:158401
Biological Process	GO:0032602	chemokine production	IGI	J:84679
Biological Process	GO:0006325	chromatin organization	IMP	J:136566
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:125955
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:106736
Biological Process	GO:0042832	defense response to protozoan	IMP	J:277857
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	IMP	J:180511
Biological Process	GO:0010467	gene expression	IMP	J:277730
Biological Process	GO:0010467	gene expression	IMP	J:136381
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:84679
Biological Process	GO:0006955	immune response	TAS	J:72250
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0016064	immunoglobulin mediated immune response	IMP	J:97662
Biological Process	GO:0009682	induced systemic resistance	IMP	J:221015
Biological Process	GO:0006954	inflammatory response	IMP	J:136381
Biological Process	GO:0006954	inflammatory response	IMP	J:221015
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IDA	J:64697
Biological Process	GO:0032635	interleukin-6 production	IMP	J:106736
Biological Process	GO:0007254	JNK cascade	ISO	J:155856
Biological Process	GO:0007254	JNK cascade	IMP	J:84679
Biological Process	GO:0002269	leukocyte activation involved in inflammatory response	IGI	J:297349
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:84679
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:110454
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:106736
Biological Process	GO:0014004	microglia differentiation	IMP	J:136381
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IMP	J:88001
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IGI	J:89998
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IMP	J:84896
Biological Process	GO:0022008	neurogenesis	IMP	J:136381
Biological Process	GO:0002283	neutrophil activation involved in immune response	IGI	J:297349
Biological Process	GO:0070944	neutrophil-mediated killing of bacterium	IGI	J:297349
Biological Process	GO:0006909	phagocytosis	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IMP	J:273550
Biological Process	GO:0032722	positive regulation of chemokine production	IGI	J:84679
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IMP	J:158401
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:84679
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032740	positive regulation of interleukin-17 production	IMP	J:131398
Biological Process	GO:0032747	positive regulation of interleukin-23 production	IMP	J:131398
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:131398
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:106736
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:84679
Biological Process	GO:0050671	positive regulation of lymphocyte proliferation	IMP	J:110454
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:110454
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:106736
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84896
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:106736
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:84896
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:145929
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:145929
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IGI	J:145929
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:84679
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IGI	J:84679
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:266673
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:89998
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:110454
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:106736
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:122812
Biological Process	GO:2000338	regulation of chemokine (C-X-C motif) ligand 1 production	IMP	J:221015
Biological Process	GO:2000341	regulation of chemokine (C-X-C motif) ligand 2 production	IMP	J:221015
Biological Process	GO:0010468	regulation of gene expression	IMP	J:146128
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:131398
Biological Process	GO:0032675	regulation of interleukin-6 production	IMP	J:221015
Biological Process	GO:1902622	regulation of neutrophil migration	IMP	J:221015
Biological Process	GO:0032680	regulation of tumor necrosis factor production	IMP	J:221015
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:110454
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:89998
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84896
Biological Process	GO:0032496	response to lipopolysaccharide	IGI	J:84896
Biological Process	GO:0002238	response to molecule of fungal origin	IMP	J:89998
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:110454
Biological Process	GO:0009615	response to virus	IMP	J:88906
Biological Process	GO:0009615	response to virus	IMP	J:97662
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0043588	skin development	IMP	J:277730
Biological Process	GO:0008063	Toll signaling pathway	ISO	J:155856
Biological Process	GO:0008063	Toll signaling pathway	IBA	J:265628
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034158	toll-like receptor 8 signaling pathway	ISO	J:164563
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	TAS	J:57233
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:84896
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:110454
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:84896
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:106736
Biological Process	GO:0032606	type I interferon production	IMP	J:97662
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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