Rock1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Rock1
Rho-associated coiled-coil containing protein kinase 1
MGI:107927

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200394
Molecular Function	GO:0005515	protein binding	IPI	J:196108
Molecular Function	GO:0005515	protein binding	IPI	J:196103
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0106003	amyloid-beta complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0010494	cytoplasmic stress granule	IDA	J:259116
Cellular Component	GO:0010494	cytoplasmic stress granule	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IDA	J:196108
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	IDA	J:196108
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:196108
Cellular Component	GO:0001726	ruffle	IDA	J:196108
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:326655
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:94515
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0030036	actin cytoskeleton organization	IGI	J:103784
Biological Process	GO:0031032	actomyosin structure organization	IBA	J:265628
Biological Process	GO:0003383	apical constriction	IGI	J:174450
Biological Process	GO:0003383	apical constriction	IGI	J:174450
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0032060	bleb assembly	IMP	J:120291
Biological Process	GO:0097746	blood vessel diameter maintenance	IMP	J:268013
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0030866	cortical actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0007010	cytoskeleton organization	ISO	J:155856
Biological Process	GO:0048598	embryonic morphogenesis	IBA	J:265628
Biological Process	GO:0001837	epithelial to mesenchymal transition	IGI	J:94515
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0050900	leukocyte migration	ISO	J:164563
Biological Process	GO:0050901	leukocyte tethering or rolling	ISO	J:164563
Biological Process	GO:0022614	membrane to membrane docking	ISO	J:164563
Biological Process	GO:0000281	mitotic cytokinesis	IBA	J:265628
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:100207
Biological Process	GO:0061157	mRNA destabilization	IMP	J:268013
Biological Process	GO:0051451	myoblast migration	IMP	J:196103
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly	ISO	J:164563
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:100207
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ISO	J:164563
Biological Process	GO:0042326	negative regulation of phosphorylation	IMP	J:278520
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0140058	neuron projection arborization	ISO	J:164563
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0090521	podocyte cell migration	IMP	J:278520
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:164563
Biological Process	GO:1905205	positive regulation of connective tissue replacement	ISO	J:164563
Biological Process	GO:0035306	positive regulation of dephosphorylation	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	IMP	J:196103
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0010922	positive regulation of phosphatase activity	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IMP	J:278520
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0032970	regulation of actin filament-based process	IGI	J:174450
Biological Process	GO:0032970	regulation of actin filament-based process	IGI	J:174450
Biological Process	GO:0110061	regulation of angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:1901888	regulation of cell junction assembly	IBA	J:265628
Biological Process	GO:0030334	regulation of cell migration	ISO	J:164563
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ISO	J:164563
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IMP	J:326655
Biological Process	GO:0090128	regulation of synapse maturation	IDA	J:326655
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	ISO	J:164563
Biological Process	GO:1990776	response to angiotensin	IGI	J:261839
Biological Process	GO:0071559	response to transforming growth factor beta	ISO	J:155856
Biological Process	GO:0071559	response to transforming growth factor beta	IGI	J:261839
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:136004
Biological Process	GO:0007165	signal transduction	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24