GO Annotations Graph

• Symbol: Ereg
• Name: epiregulin
• ID: MGI:107508

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IDA	J:113686
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:247650
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:47407
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:113686
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:247650
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:47407
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:47407
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:47407
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:52619
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:47407
Cellular Component	GO:0005615	extracellular space	ISO	J:247650
Cellular Component	GO:0005615	extracellular space	IGI	J:247650
Cellular Component	GO:0005615	extracellular space	ISO	J:47407
Cellular Component	GO:0005615	extracellular space	ISO	J:47407
Cellular Component	GO:0005615	extracellular space	ISO	J:47407
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0009653	anatomical structure morphogenesis	TAS	J:52619
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0009887	animal organ morphogenesis	TAS	J:52619
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISS	J:114807
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:113686
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:247650
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:47407
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:247650
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	ISO	J:47407
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	ISO	J:47407
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:47407
Biological Process	GO:0007143	female meiotic nuclear division	ISO	J:155856
Biological Process	GO:0043616	keratinocyte proliferation	ISO	J:164563
Biological Process	GO:0042700	luteinizing hormone signaling pathway	ISO	J:155856
Biological Process	GO:0009299	mRNA transcription	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IDA	J:113686
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0051151	negative regulation of smooth muscle cell differentiation	ISO	J:164563
Biological Process	GO:0001556	oocyte maturation	ISO	J:155856
Biological Process	GO:0001550	ovarian cumulus expansion	ISO	J:155856
Biological Process	GO:0030728	ovulation	ISO	J:155856
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:113686
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:101520
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	IDA	J:113686
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	ISS	J:113796
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0045740	positive regulation of DNA replication	IDA	J:52619
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISS	J:113796
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:155856
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	IBA	J:265628
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:101520
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:101520
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISS	J:113796
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IDA	J:113686
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:155856
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IBA	J:265628
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISS	J:114807
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISS	J:113796
Biological Process	GO:0048160	primary follicle stage	ISO	J:155856