GO Annotations Graph

• Symbol: Notch4
• Name: notch 4
• ID: MGI:107471

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005112	Notch binding	IBA	J:265628
Molecular Function	GO:0005112	Notch binding	IPI	J:212472
Molecular Function	GO:0005515	protein binding	IPI	J:156081
Molecular Function	GO:0005515	protein binding	IPI	J:167379
Molecular Function	GO:0005515	protein binding	IPI	J:40289
Molecular Function	GO:0005515	protein binding	IPI	J:167379
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:212472
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9604677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9605444
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9604300
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:212472
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9013699
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9604511
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9604617
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9604628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9604648
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9604251
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9604278
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-2168986
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-9604300
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:69406
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:72247
Biological Process	GO:0045446	endothelial cell differentiation	ISO	J:155856
Biological Process	GO:0001886	endothelial cell morphogenesis	ISO	J:155856
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0030879	mammary gland development	ISO	J:164563
Biological Process	GO:0001763	morphogenesis of a branching structure	IMP	J:69406
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060354	negative regulation of cell adhesion molecule production	ISO	J:164563
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	ISO	J:164563
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation	IMP	J:69406
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IDA	J:212472
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:69406
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:212472
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:212472
Biological Process	GO:1903849	positive regulation of aorta morphogenesis	IMP	J:144857
Biological Process	GO:0050793	regulation of developmental process	IEA	J:72247
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0008593	regulation of Notch signaling pathway	IGI	J:212472
Biological Process	GO:0032880	regulation of protein localization	IDA	J:212472
Biological Process	GO:0070613	regulation of protein processing	IDA	J:212472
Biological Process	GO:0001944	vasculature development	IMP	J:69406
Biological Process	GO:0048845	venous blood vessel morphogenesis	IMP	J:144857