Numb GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Numb
NUMB endocytic adaptor protein
MGI:107423

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045294	alpha-catenin binding	IPI	J:124218
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:124218
Molecular Function	GO:0045296	cadherin binding	IPI	J:124218
Molecular Function	GO:0045296	cadherin binding	IPI	J:124218
Molecular Function	GO:0005515	protein binding	IPI	J:213895
Molecular Function	GO:0005515	protein binding	IPI	J:175332
Molecular Function	GO:0005515	protein binding	IPI	J:127227
Molecular Function	GO:0005515	protein binding	IPI	J:310319
Molecular Function	GO:0005515	protein binding	IPI	J:310319
Molecular Function	GO:0005515	protein binding	IPI	J:73266
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	IDA	J:79396
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0045177	apical part of cell	IDA	J:171504
Cellular Component	GO:0016323	basolateral plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:124218
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:227201
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:215867
Cellular Component	GO:0031410	cytoplasmic vesicle	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005769	early endosome	IDA	J:73901
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:228200
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:228200
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2077477
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2077479
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0034332	adherens junction organization	IGI	J:124218
Biological Process	GO:0007409	axonogenesis	IDA	J:95688
Biological Process	GO:0007409	axonogenesis	IMP	J:95688
Biological Process	GO:0030900	forebrain development	IMP	J:87149
Biological Process	GO:0021670	lateral ventricle development	IMP	J:127227
Biological Process	GO:0060487	lung epithelial cell differentiation	IMP	J:171504
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IMP	J:171504
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:62712
Biological Process	GO:0007399	nervous system development	IMP	J:87149
Biological Process	GO:0021849	neuroblast division in subventricular zone	IMP	J:127227
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:79917
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:79917
Biological Process	GO:0050769	positive regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0030862	positive regulation of polarized epithelial cell differentiation	IMP	J:171504
Biological Process	GO:0045664	regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0150052	regulation of postsynapse assembly	ISO	J:155856
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IDA	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IEP	J:228200
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	IMP	J:228200

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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