GO Annotations Graph

• Symbol: Ccr5
• Name: C-C motif chemokine receptor 5
• ID: MGI:107182

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0019957	C-C chemokine binding	IPI	J:40322
Molecular Function	GO:0019957	C-C chemokine binding	ISO	J:164563
Molecular Function	GO:0016493	C-C chemokine receptor activity	ISO	J:164563
Molecular Function	GO:0016493	C-C chemokine receptor activity	ISO	J:68942
Molecular Function	GO:0016493	C-C chemokine receptor activity	IDA	J:32263
Molecular Function	GO:0071791	chemokine (C-C motif) ligand 5 binding	ISO	J:164563
Molecular Function	GO:0071791	chemokine (C-C motif) ligand 5 binding	IBA	J:265628
Molecular Function	GO:0004950	chemokine receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:200103
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:68942
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:118845
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:197348
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	IEA	J:72247
Biological Process	GO:0006952	defense response	IMP	J:64293
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0030517	negative regulation of axon extension	ISO	J:155856
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	IDA	J:102878
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	ISO	J:155856
Biological Process	GO:0070997	neuron death	ISO	J:155856
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0031622	positive regulation of fever generation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:164563
Biological Process	GO:0070723	response to cholesterol	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000