GO Annotations Graph

• Symbol: Cdkn2a
• Name: cyclin dependent kinase inhibitor 2A
• ID: MGI:104738

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:24521
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:77997
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:28319
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	IPI	J:72910
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:143694
Molecular Function	GO:0005515	protein binding	IPI	J:296094
Molecular Function	GO:0005515	protein binding	IPI	J:171888
Molecular Function	GO:0005515	protein binding	IPI	J:189986
Molecular Function	GO:0005515	protein binding	IPI	J:207374
Molecular Function	GO:0005515	protein binding	IPI	J:193629
Molecular Function	GO:0005515	protein binding	IPI	J:94162
Molecular Function	GO:0005515	protein binding	IPI	J:94174
Molecular Function	GO:0005515	protein binding	IPI	J:94174
Molecular Function	GO:0005515	protein binding	IPI	J:99711
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:1990948	ubiquitin ligase inhibitor activity	ISO	J:164563
Molecular Function	GO:0055105	ubiquitin-protein transferase inhibitor activity	IDA	J:51904
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:79357
Cellular Component	GO:0001652	granular component	IDA	J:79357
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:94162
Cellular Component	GO:0005730	nucleolus	IDA	J:94174
Cellular Component	GO:0005730	nucleolus	IDA	J:72910
Cellular Component	GO:0005730	nucleolus	IDA	J:101353
Cellular Component	GO:0005730	nucleolus	IDA	J:138546
Cellular Component	GO:0005730	nucleolus	IDA	J:99711
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IMP	J:72910
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:72247
Biological Process	GO:0060057	apoptotic process involved in mammary gland involution	IMP	J:91428
Biological Process	GO:0000422	autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IDA	J:94174
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:198334
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IMP	J:178645
Biological Process	GO:0090398	cellular senescence	IGI	J:72780
Biological Process	GO:0090398	cellular senescence	IDA	J:190763
Biological Process	GO:0090398	cellular senescence	IDA	J:74741
Biological Process	GO:0008544	epidermis development	IMP	J:72780
Biological Process	GO:0008544	epidermis development	IGI	J:72780
Biological Process	GO:0042593	glucose homeostasis	IMP	J:209560
Biological Process	GO:0042593	glucose homeostasis	IMP	J:209560
Biological Process	GO:0030216	keratinocyte differentiation	IGI	J:72780
Biological Process	GO:0043616	keratinocyte proliferation	IGI	J:72780
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:91428
Biological Process	GO:0051882	mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:105559
Biological Process	GO:0045786	negative regulation of cell cycle	IDA	J:94174
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	IMP	J:79357
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:24521
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:77997
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0033088	negative regulation of immature T cell proliferation in thymus	IMP	J:105559
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	IMP	J:91428
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0042326	negative regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	IDA	J:193629
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:2000435	negative regulation of protein neddylation	ISO	J:164563
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	IDA	J:193629
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	ISO	J:164563
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IDA	J:193629
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	IDA	J:51904
Biological Process	GO:0090402	oncogene-induced cell senescence	IMP	J:72780
Biological Process	GO:0090402	oncogene-induced cell senescence	IGI	J:72780
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	IMP	J:91428
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IC	J:51904
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:144234
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:144234
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:2000111	positive regulation of macrophage apoptotic process	IGI	J:170042
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0033235	positive regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:1901798	positive regulation of signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	IGI	J:170042
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:1902510	regulation of apoptotic DNA fragmentation	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:28319
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:28319
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	IGI	J:79357
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:70387
Biological Process	GO:0010468	regulation of gene expression	IMP	J:70387
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	IGI	J:94174
Biological Process	GO:0046825	regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	IMP	J:79357
Biological Process	GO:1903214	regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0090399	replicative senescence	ISO	J:164563
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0010243	response to organonitrogen compound	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0006364	rRNA processing	IEA	J:60000
Biological Process	GO:0009303	rRNA transcription	IGI	J:142821
Biological Process	GO:0048103	somatic stem cell division	IMP	J:105559
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:144068