GO Annotations Graph

• Symbol: Vdr
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
• ID: MGI:103076

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1902098	calcitriol binding	ISO	J:155856
Molecular Function	GO:1902098	calcitriol binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:76833
Molecular Function	GO:0003677	DNA binding	IDA	J:95384
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:1902121	lithocholic acid binding	ISO	J:164563
Molecular Function	GO:0038186	lithocholic acid receptor activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:155856
Molecular Function	GO:0004879	nuclear receptor activity	IBA	J:265628
Molecular Function	GO:0004879	nuclear receptor activity	IDA	J:94471
Molecular Function	GO:0046965	nuclear retinoid X receptor binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:236712
Molecular Function	GO:0005515	protein binding	IPI	J:196119
Molecular Function	GO:0005515	protein binding	IPI	J:37212
Molecular Function	GO:0005515	protein binding	IPI	J:244975
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0036094	small molecule binding	ISO	J:164563
Molecular Function	GO:0005499	vitamin D binding	ISO	J:155856
Molecular Function	GO:0070644	vitamin D response element binding	ISO	J:164563
Molecular Function	GO:0070644	vitamin D response element binding	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0001651	dense fibrillar component	ISO	J:155856
Cellular Component	GO:0000791	euchromatin	ISO	J:155856
Cellular Component	GO:0000792	heterochromatin	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016363	nuclear matrix	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:42054
Biological Process	GO:0060057	apoptotic process involved in mammary gland involution	IMP	J:92080
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0038183	bile acid signaling pathway	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:72578
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0000902	cell morphogenesis	ISO	J:164563
Biological Process	GO:0050892	intestinal absorption	IMP	J:72578
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:42054
Biological Process	GO:0007595	lactation	IMP	J:92080
Biological Process	GO:0060745	mammary gland branching involved in pregnancy	IMP	J:92080
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IMP	J:42054
Biological Process	GO:1900155	negative regulation of bone trabecula formation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:76833
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0035435	phosphate ion transmembrane transport	ISO	J:164563
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	IMP	J:92080
Biological Process	GO:0030501	positive regulation of bone mineralization	NAS	J:319681
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:2000830	positive regulation of parathyroid hormone secretion	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	ISO	J:164563
Biological Process	GO:0070564	positive regulation of vitamin D receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060558	regulation of calcidiol 1-monooxygenase activity	IMP	J:43146
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:94471
Biological Process	GO:1903412	response to bile acid	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	IMP	J:42054
Biological Process	GO:0070561	vitamin D receptor signaling pathway	ISO	J:164563