GO Annotations Graph

• Symbol: Ddx3x
• Name: DEAD box helicase 3, X-linked
• ID: MGI:103064

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0043273	CTPase activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003678	DNA helicase activity	ISO	J:164563
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding	ISO	J:164563
Molecular Function	GO:0043015	gamma-tubulin binding	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0048027	mRNA 5'-UTR binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008143	poly(A) binding	ISO	J:164563
Molecular Function	GO:0070878	primary miRNA binding	IDA	J:258363
Molecular Function	GO:0005515	protein binding	IPI	J:279977
Molecular Function	GO:0005515	protein binding	IPI	J:200396
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0017111	ribonucleoside triphosphate phosphatase activity	ISO	J:164563
Molecular Function	GO:0043024	ribosomal small subunit binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IBA	J:265628
Molecular Function	GO:0003724	RNA helicase activity	ISO	J:164563
Molecular Function	GO:0003724	RNA helicase activity	IBA	J:265628
Molecular Function	GO:0035613	RNA stem-loop binding	ISO	J:164563
Molecular Function	GO:0033592	RNA strand annealing activity	ISO	J:164563
Molecular Function	GO:0035591	signaling adaptor activity	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	ISO	J:164563
Molecular Function	GO:0031369	translation initiation factor binding	ISO	J:164563
Cellular Component	GO:0061702	canonical inflammasome complex	IEA	J:60000
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0010494	cytoplasmic stress granule	ISO	J:164563
Cellular Component	GO:0010494	cytoplasmic stress granule	IDA	J:279977
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	ISO	J:164563
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0072559	NLRP3 inflammasome complex	IDA	J:279977
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0043186	P granule	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071243	cellular response to arsenic-containing substance	ISO	J:164563
Biological Process	GO:0071470	cellular response to osmotic stress	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0007059	chromosome segregation	ISO	J:164563
Biological Process	GO:0042256	cytosolic ribosome assembly	ISO	J:164563
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0007276	gamete generation	IBA	J:265628
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0055088	lipid homeostasis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:279977
Biological Process	GO:1901985	positive regulation of protein acetylation	ISO	J:164563
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:164563
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	ISO	J:164563
Biological Process	GO:0034161	positive regulation of toll-like receptor 8 signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0045948	positive regulation of translational initiation	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0045070	positive regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0031053	primary miRNA processing	IMP	J:258363
Biological Process	GO:0031053	primary miRNA processing	IDA	J:258363
Biological Process	GO:1903608	protein localization to cytoplasmic stress granule	ISO	J:164563
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0009615	response to virus	ISO	J:164563
Biological Process	GO:0042254	ribosome biogenesis	IEA	J:60000
Biological Process	GO:0010501	RNA secondary structure unwinding	ISO	J:164563
Biological Process	GO:0034063	stress granule assembly	ISO	J:164563
Biological Process	GO:0034063	stress granule assembly	IMP	J:279977
Biological Process	GO:0006413	translational initiation	ISO	J:164563
Biological Process	GO:0016055	Wnt signaling pathway	ISO	J:164563