GO Annotations Graph

• Symbol: Six2
• Name: sine oculis-related homeobox 2
• ID: MGI:102778

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:93877
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:93877
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:187563
Molecular Function	GO:0005515	protein binding	IPI	J:124751
Molecular Function	GO:0005515	protein binding	IPI	J:212814
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:129070
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:93877
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:93877
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:93877
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:35368
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	IPI	J:188777
Molecular Function	GO:0008134	transcription factor binding	IPI	J:208647
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:93877
Cellular Component	GO:0005634	nucleus	IDA	J:35368
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Biological Process	GO:0009948	anterior/posterior axis specification	IDA	J:135823
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IMP	J:163483
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:163483
Biological Process	GO:0072137	condensed mesenchymal cell proliferation	IGI	J:226938
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:163483
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	IMP	J:153643
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IGI	J:95309
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:115344
Biological Process	GO:0001822	kidney development	IMP	J:115344
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0001822	kidney development	IBA	J:265628
Biological Process	GO:0072161	mesenchymal cell differentiation involved in kidney development	IMP	J:115344
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	IDA	J:188777
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	IMP	J:171512
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	IDA	J:208647
Biological Process	GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis	IMP	J:148455
Biological Process	GO:0097168	mesenchymal stem cell proliferation	IMP	J:171512
Biological Process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	IEP	J:54493
Biological Process	GO:0007501	mesodermal cell fate specification	IDA	J:129070
Biological Process	GO:0001656	metanephros development	IMP	J:115344
Biological Process	GO:0042474	middle ear morphogenesis	IGI	J:95309
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	IMP	J:115344
Biological Process	GO:0072006	nephron development	IMP	J:148455
Biological Process	GO:0072028	nephron morphogenesis	IMP	J:115344
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	IMP	J:163483
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:93877
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:93877
Biological Process	GO:0006606	protein import into nucleus	IDA	J:103131
Biological Process	GO:0090189	regulation of branching involved in ureteric bud morphogenesis	IMP	J:115344
Biological Process	GO:0032330	regulation of chondrocyte differentiation	IMP	J:163483
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0030278	regulation of ossification	IMP	J:163483
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628