GO Annotations Graph

• Symbol: Lhx3
• Name: LIM homeobox protein 3
• ID: MGI:102673

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:161034
Molecular Function	GO:0005515	protein binding	IPI	J:200395
Molecular Function	GO:0005515	protein binding	IPI	J:56497
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:328860
Molecular Function	GO:0001223	transcription coactivator binding	IPI	J:328860
Molecular Function	GO:0001221	transcription coregulator binding	IPI	J:328860
Cellular Component	GO:0000785	chromatin	IDA	J:328860
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:57340
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9010548
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:156251
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:328860
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:41049
Biological Process	GO:0006915	apoptotic process	IMP	J:130185
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:130185
Biological Process	GO:0021526	medial motor column neuron differentiation	IGI	J:51420
Biological Process	GO:0008045	motor neuron axon guidance	IGI	J:51420
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:130185
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0021983	pituitary gland development	IMP	J:130185
Biological Process	GO:0001890	placenta development	IGI	J:134683
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:172915
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:328860
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:328860
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:41049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41049
Biological Process	GO:0060127	prolactin secreting cell differentiation	IMP	J:33050
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0060126	somatotropin secreting cell differentiation	IMP	J:33050
Biological Process	GO:0021527	spinal cord association neuron differentiation	IDA	J:147271
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	IGI	J:152175
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	IGI	J:152175
Biological Process	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	IMP	J:33050
Biological Process	GO:0021521	ventral spinal cord interneuron specification	IDA	J:152175