Tg(SNCA*)1Ryot
Transgene Detail

Summary

• Symbol: Tg(SNCA*)1Ryot
• Name: transgene insertion 1, Ryosuke Takahashi
• MGI ID: MGI:8378106
• Synonyms: BAC-SNCA^A53T
• Transgene: Tg(SNCA*)1Ryot Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Tg(SNCA*)1Ryot page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SNCA*)1Ryot expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  Modified BAC that contains A53T mutation, two risk SNPs, and Rep1 copy number variation.

• Mutation details: The transgene consists of the PAC AF163864 and BAC AC097478 and contains 28 kb of the 5' and 50 kb of the 3' flanking sequences in addition to the entire human SNCA gene. An A53T mutation, two risk SNPs, rs11931074 (G to T) and rs3857059 (A to G), as well as a Rep1 dinucleotide repeat polymorphism copy number variation (259 to 261 repeats) in the 5 region of SNCA, were introduced into this BAC construct using Red/ET recombination system in order to enhance alpha-synuclein expression and aggregation to create symptomatic mice model for Parkinsons disease. FISH analysis indicated that the transgene inserted on Chromosome 9. (J:302679)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:302679 Taguchi T, et al., alpha-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model. Brain. 2020 Jan 1;143(1):249-265
• All: 3 reference(s)