Phenotypes associated with this allele

• Allele Symbol: Tg(SNCA*)1Ryot
• Allele Name: transgene insertion 1, Ryosuke Takahashi
• Allele ID: MGI:8378106
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(SNCA*)1Ryot/0	C57BL/6J-Tg(SNCA*)1Ryot	MGI:8378108

Genotype
MGI:8378108

tg1

• Allelic Composition: Tg(SNCA*)1Ryot/0
• Genetic Background: C57BL/6J-Tg(SNCA*)1Ryot

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:302679 )

N • 9-month-old mice show no differences in the rotarod test, light and dark transition test, Y-maze test and Barnes maze test

abnormal sleep behavior ( J:302679 )

• mice exhibit excessive muscle twitches in the body and limbs during REM sleep which are accompanied by transient increases in muscle activity; analysis indicates higher electromyography (EMG) variances during REM sleep at 11 and 13 months of age, although tendencies are already present at 5 months of age, and suggests that mice experience REM sleep without atonia

• neck EMG variance during REM sleep is elevated by more than 180% compared to that during NREM sleep compared to 100% in controls, however there is no difference in total time and duration of awake/NREM/REM sleep

nervous system

abnormal substantia nigra pars compacta morphology ( J:302679 )

• degeneration of dopaminergic neurons in the substantia nigra pars compacta as evidenced by a decrease in TH+ neurons in the substantia nigra pars compacta, but not in the ventral tegmental area

neuron degeneration ( J:302679 )

• degeneration of dopaminergic neurons in the substantia nigra pars compacta

• degree of neuronal loss is more severe in the dorsal part (SNcd) than in other regions of the substantia nigra pars compacta

alpha-synuclein inclusion body ( J:302679 )

• alpha-synuclein aggregates are seen in nerve terminals

• increase in oligomeric alpha-synuclein species in the substantia nigra pars compacta

taste/olfaction

impaired olfaction ( J:302679 )

• 9-month-old males spend less time sniffing female urine in the olfactory preference test

• in the olfactory avoidance test, mice show a longer stay time in the hexanone area than wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lewy body dementia		DOID:12217	OMIM:127750	J:302679
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:302679
REM sleep behavior disorder		DOID:9091		J:302679