Del(7Chrna7-Fan1)3Arte Cytogenetic Marker Detail

Summary

• Symbol
  Del(7Chrna7-Fan1)3Arte
• Name
  deletion, Chr 7, TaconicArtemis

• Feature Type
  chromosomal deletion
• IDs
  MGI:6150621

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, Syntenic

Human Diseases

• Diseases
  1 with Del(7Chrna7-Fan1)3Arte mouse models

Human Disease

Mouse Models

chromosome 15q13.3 microdeletion syndrome

IDs

chromosome 15q13.3 microdeletion syndrome      

DOID:0060394
ICD10CM:Q93.5
MESH:C567439
OMIM:612001
ORDO:199318

View 1 model

Mouse Models

Human Disease Modeled: chromosome 15q13.3 microdeletion syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Del(7Chrna7-Fan1)3Arte/+	involves: C57BL/6J * C57BL/6NTac	J:260165	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Male mice hemizygous for this deletion exhibit increased postnatal lethality, increased body weight, increased aggression, imapired spatial learning, reduced startle reflex, reduced LDAEP, and protection from electroshock- and nicotine-induced seizure.

References

• Summaries
  All 5

  Diseases 1

  Phenotypes 4
• Earliest
  J:260165 Fejgin K, et al., A mouse model that recapitulates cardinal features of the 15q13.3 microdeletion syndrome including schizophrenia- and epilepsy-related alterations. Biol Psychiatry. 2014 Jul 15;76(2):128-37
• Latest
  J:322231 Malwade S, et al., Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics. Biol Psychiatry. 2022 Apr 15;91(8):727-739