Tg(Myh6-CRYAB*R120G)7302Ijb
Transgene Detail

Summary

• Symbol: Tg(Myh6-CRYAB*R120G)7302Ijb
• Name: transgene insertion 7302, Ivor J Benjamin
• MGI ID: MGI:6103872
• Synonyms: hR120GCryAB High Tg
• Transgene: Tg(Myh6-CRYAB*R120G)7302Ijb Location: unknown
• Alliance: Tg(Myh6-CRYAB*R120G)7302Ijb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-CRYAB*R120G)7302Ijb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cryab (MGI:88516)

• Mutation details: The mouse alpha-myosin heavy chain promoter drives the expression of the human alphaB-crystallin with the missense R120G mutation. Two lines were established: 7302 and 7313. Total Cryab protein, both endogenous and transgene expression, is increased 6-fold in this line. (J:126781)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:126781 Rajasekaran NS, et al., Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10;130(3):427-39
• All: 4 reference(s)