Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
G6pdxa-m1Neu mutation
(2 available);
any
G6pdx mutation
(7 available)
Tg(Myh6-CRYAB*R120G)7302Ijb mutation
(0 available)
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cardiovascular system
N |
• mice do not exhibit cardiac hypertrophy, show normal glucose-6-phosphate dehydrogenase enzyme activity in the heart and cardiomyocyte survival, and no protein aggregation in the heart
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• 100% mortality at 66 weeks of age
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cardiovascular system
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• large protein aggregates in myocardium
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• heart weight/body weight ratio is 33% greater than in non-transgenic mice at 6 months of age
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• cardiac hypertrophy by 6 months of age, with gross four-chamber enlargement
• markers of cardiac hypertrophy are increased in 3 and 6 month old mice
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• severe ventricular remodeling with dilatation at end-stage
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• viability of isolated cardiomyocytes is decreased
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• progressive heart failure
• markers of congestive heart failure are increased in 3 and 6 month old mice
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behavior/neurological
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• disease progression accelerates after 6 months, with increased lethargy
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homeostasis/metabolism
muscle
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• large protein aggregates in myocardium
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growth/size/body
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• heart weight/body weight ratio is 33% greater than in non-transgenic mice at 6 months of age
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• markers of cardiac hypertrophy are increased in 3 and 6 month old mice
• cardiac hypertrophy by 6 months of age, with gross four-chamber enlargement
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