Tg(Myh6/tetO-Cacnb2*)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Cacnb2*)1Jmol
• Name: transgene insertion 1, Jeffery Molkentin
• MGI ID: MGI:5897302
• Transgene: Tg(Myh6/tetO-Cacnb2*)1Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-Cacnb2*)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-Cacnb2*)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Cacnb2 (116600)

  Cacnb2

  (MGI:894644)

• Tg(Myh6/tetO-Cacnb2*)1Jmol expression driven by 2 genes
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)
  Not Specified	tetO

• Mutation details: Mice bearing this transgene express a C3S/C4S palmitoylation-deficient mutant form of rat CACNB2 (calcium channel, voltage-dependent, beta 2 subunit; an L-type Ca<2+> channel (LTCC) activator) fused to the canonical caveolin binding domain (CBD; RNVPPIFNDVYWIAF) under the conditional control of the mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter and the tetracycline-responsive element (TRE or tetO). Expression of the transgene is robust as determined by western blot. (J:263301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:263301 Correll RN, et al., Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovasc Res. 2017 Jun 1;113(7):749-759
• All: 1 reference(s)