Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
Transgene Detail

Summary

• Symbol: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx
• Name: transgene insertion, Steven O Marx
• MGI ID: MGI:5800483
• Synonyms: F1759A-Nav1.5
• Transgene: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx Location: unknown
• Alliance: Tg(Myh6*/tetO-SCN5A*F1759A)#Marx page

Atrial and ventricular cardiomyopathy in Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6*/tetO-SCN5A*F1759A)#Marx expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SCN5A (6331)

  Scn5a

  (MGI:98251)

• Mutation details: A FLAG-tagged human SCN5A cDNA with the F1759A mutation in the local anesthetic binding site is under the control of a tetracycline-inducible modified murine alpha-MHC promoter. This mutation results in lidocaine-resistance and causes window current and persistent sodium current. Four lines were established however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:229825)

Schematic of the Tg(Myh6*/tetO-SCN5A*F1759A)#Marx construct

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:229825 Wan E, et al., Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice. J Clin Invest. 2016 Jan;126(1):112-22
• All: 4 reference(s)