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Caption Increased persistent Na+ current is sufficient to initiate structural changes in the atria and ventricles of Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 (F1759A-dTG) mice. (A) Photographs of littermate control (CONT) and double mutant (F1759A-dTG) hearts at 4 weeks and 3.5 months after birth. (B) H&E-stained cross section of ventricle. Scale bars: 1 mm. (E) H&E stain of right and left atria showing bi-atrial enlargement in double mutant mice. Scale bars: 1 mm. Bar graph of left atrial and right atrial area of littermate control and double mutant mice at 3-4 months of age. Data are presented as mean +/- SEM. *P < 0.05; t test. n = 5 for each group. (F) Masson's trichrome stain of atria of littermate control and mutant mice. Scale bars: 50 um. Bar graph quantifying atrial fibrosis. Data are presented as mean +/- SEM. *P < 0.05; t test. n >= 5 for each group. (G) Representative 2-dimensional TEM images (n = 2 for F1759A-dTG and littermate control) showing left to right, gross morphology of atrial and ventricular samples at 6 weeks (first row) and 12 weeks (second and third rows) in littermate control mice compared with F1759A-dTG mice. At 6 weeks, F1758A-dTG mice show signs of myofibril disarray with loss of congruous parallel myofibrils in the atrium. By 12 weeks of age, atrial and ventricular cardiomyocytes from the mutant mice demonstrated mitochondrial injury, with circular and swollen mitochondria and ruptured outer membranes. In the ventricle, the red arrows point to T-tubule cross sections, which are larger in the mutant mice compared with littermate control. Scale bars: 500 nm.
Copyright This image is from Wan E, J Clin Invest 2016 Jan;126(1):112-22 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:229825
Symbol Name
Tg(Myh6-rtTA)8585Jam transgene insertion 8585, John A McDonald
Tg(Myh6*/tetO-SCN5A*F1759A)#Marx transgene insertion, Steven O Marx
Allelic Composition Genetic Background
involves: C57BL/6 * CBA * FVB/NTac

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