Tg(Tyr)TashTNpln
Transgene Detail

Summary

• Symbol: Tg(Tyr)TashTNpln
• Name: transgene insertion TashT, Nicolas Pilon
• MGI ID: MGI:5755287
• Synonyms: TashT^Tg, Tg(SRY-YFP,Tyr)TashTNpln
• Transgene: Tg(Tyr)TashTNpln Location: Chr10:45453925-49664862 bp Genetic Position: Chr10, Syntenic
• Alliance: Tg(Tyr)TashTNpln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Multiple copies of a tyrosinase minigene (consisting of the Tyr distal enhancer in reverse orientation upstream of the proximal promoter and complete Tyr cDNA) integrated into a 3.3 Mb gene dessert containing highly conserved elements on chromosome 10 between Hace1 and Grik2. An ~26 kb region was duplicated during transgene integration The transgene was co-injected, and co-integrated, with the Tg(SRY-YFP)p16Svs transgene. This Tachetee line was generated in a forward genetic screen aimed at identifying genes with key roles in neural crest cells. (J:224231)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:224231 Bergeron KF, et al., Male-biased aganglionic megacolon in the TashT mouse line due to perturbation of silencer elements in a large gene desert of chromosome 10. PLoS Genet. 2015 Mar;11(3):e1005093
• All: 4 reference(s)