Tg(Camk2a-Grik2)28Cmul
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Grik2)28Cmul
• Name: transgene insertion 28, Christophe Mulle
• MGI ID: MGI:5645814
• Transgene: Tg(Camk2a-Grik2)28Cmul Location: unknown
• Alliance: Tg(Camk2a-Grik2)28Cmul page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-Grik2)28Cmul expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Grik2 (54257)

  Grik2

  (MGI:95815)

• Mutation details: Six consecutive c-myc epitopes were introduced after the signal sequence of rat GluR6 (Grik2) cDNA. This construct was expressed by an 8.5 kB Ca2+-calmodulin-dependent protein kinase II (CaMKIIalpha) promoter. Six lines were created, including 23, 26 and 28. Differing genomic integration positions generated mouse lines with a variable pattern of expression of the transgene. In line 28, the construct was evenly expressed in the hippocampus, the neocortex, and the striatum, whereas in others, the expression was more abundant in a particular brain region (neocortex for line 23, hippocampus for line 26). Line 28 was expanded for further study. (J:78109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:78109 Coussen F, et al., Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. J Neurosci. 2002 Aug 1;22(15):6426-36
• All: 2 reference(s)