Tg(Prnp-FUS*H517Q)29Ljh
Transgene Detail

Summary

• Symbol: Tg(Prnp-FUS*H517Q)29Ljh
• Name: transgene insertion 29, Lawrence Hayward
• MGI ID: MGI:5621051
• Synonyms: FUS^H517Q, line PQ29, PrP-hFUS(H517Q)
• Transgene: Tg(Prnp-FUS*H517Q)29Ljh Location: unknown
• Alliance: Tg(Prnp-FUS*H517Q)29Ljh page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-FUS*H517Q)29Ljh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FUS (2521)

  Fus	(MGI:1353633)

  human fused in sarcoma H517Q mutant isoform (hFUS*H517Q) that is associated with amyotrophic lateral sclerosis (ALS)

• Mutation details: The transgenic construct contains a cDNA sequence encoding the human fused in sarcoma H517Q mutant isoform (hFUS*H517Q) associated with amyotrophic lateral sclerosis (ALS). The cDNA sequence is inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene. Line PQ29 is identified with ~2-4 copies of the transgene. The transgene encodes an autosomal recessive missense mutation in the nuclear localization signal at the C-terminus of FUS, resulting in mild mislocalization within the cytoplasm. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)