Tg(SFTPC-cre/ERT2)#Hbji
Transgene Detail

Summary

• Symbol: Tg(SFTPC-cre/ERT2)#Hbji
• Name: transgene insertion, Hongbin Ji
• MGI ID: MGI:5555031
• Synonyms: SP-C-CreERT2
• Transgene: Tg(SFTPC-cre/ERT2)#Hbji Location: unknown
• Alliance: Tg(SFTPC-cre/ERT2)#Hbji page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(SFTPC-cre/ERT2)#Hbji expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  SFTPC (6440)

  Sftpc

  (MGI:109517)

• Mutation details: A DNA fragment encoding the cre/ERT2 fusion protein with an SV40 poly A sequence was ligated to the 3.7 kb human surfactant protein C (SFTPC) promoter. The construct was injected into FVB/N blastocysts. Founder and line information is not available. (J:206810)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	SFTPC (human) Summary of all recombinase alleles driven by SFTPC. Alliance human SFTPC gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:206810 Han X, et al., Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun. 2014 Feb 17;5:3261
• All: 1 reference(s)