Tg(Prnp-PSEN2*N141I)30Jgr
Transgene Detail

Summary

• Symbol: Tg(Prnp-PSEN2*N141I)30Jgr
• Name: transgene insertion 30, J Richards
• MGI ID: MGI:4839766
• Synonyms: PS2.30H
• Transgene: Tg(Prnp-PSEN2*N141I)30Jgr Location: unknown
• Alliance: Tg(Prnp-PSEN2*N141I)30Jgr page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PSEN2*N141I)30Jgr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN2 (5664)

  Psen2

  (MGI:109284)

  Transgene codes for a protein with an asparagine to isoleucine mutation.

• Mutation details: The Prnp promoter driving the expression of human PSEN2 with the familial Alzheimer disease mutation N141I. Line 30 was generated. (J:88193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88193 Richards JG, et al., PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J Neurosci. 2003 Oct 1;23(26):8989-9003
• All: 12 reference(s)