Tg(HLA-DRA,HLA-DRB1*0301)#Gjh
Transgene Detail

Summary

• Symbol: Tg(HLA-DRA,HLA-DRB1*0301)#Gjh
• Name: transgene insertion, Gunter J Hammerling
• MGI ID: MGI:4460916
• Synonyms: DR3(DRwl7)
• Transgene: Tg(HLA-DRA,HLA-DRB1*0301)#Gjh Location: unknown
• Alliance: Tg(HLA-DRA,HLA-DRB1*0301)#Gjh page

Transgene origin

• Strain of Origin: (C57BL/6 X DBA/2)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-DRA,HLA-DRB1*0301)#Gjh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLA-DRA (3122)

  H2-Ea

  (MGI:95900)

• Mutation details: A 6kb fragment from a genomic clone of HLA-DRA and a 24 kb fragment of HLA-DRB1*0301 were coinjected into fertilized eggs. Transgene expression was confirmed by Northern blot analysis. (J:161691)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:161691 Strauss G, et al., Negative and positive selection by HLA-DR3(DRw17) molecules in transgenic mice. Immunogenetics. 1994;40(2):104-8
• All: 6 reference(s)