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Tg(Igh-V186.2-TCL1A)3Cro
Transgene Detail
Summary
Symbol: Tg(Igh-V186.2-TCL1A)3Cro
Name: transgene insertion 3, Carlo M Croce
MGI ID: MGI:3527221
Synonyms: EmuTCL1, Emu-TCL1, TCL1-Tg, TG line 3
Transgene: Tg(Igh-V186.2-TCL1A)3Cro  Location: unknown  
Alliance: Tg(Igh-V186.2-TCL1A)3Cro page
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igh-V186.2-TCL1A)3Cro expresses 1 gene
 
Mutation detailsA 350 bp fragment encoding the entire human TCL1A coding region was placed under the transcriptional control of the mouse Igh-V186.2 promoter and the Igh-mu enhancer sequence. 3'UTR and polyA sequences were derived from the human Beta-globin gene. Transgene expression was detected in the spleen and bone marrow, but not the liver. (J:76574)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(Igh-V186.2-TCL1A)3Cro
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:76574 Bichi R, et al., Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6955-60
All:  108 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory