All Phenotypes Tg(Igh-V186.2-TCL1A)3Cro MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Igh-ROR1)1Kip/0 Tg(Igh-V186.2-TCL1A)3Cro/0	B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro	MGI:5571374
cx2	Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0 Tg(Igh-V186.2-TCL1A)3Cro/0	involves: C3H * C57BL/6 * FVB/N	MGI:4820822
tg3	Tg(Igh-V186.2-TCL1A)3Cro/0	B6.Cg-Tg(Igh-V186.2-TCL1A)3Cro	MGI:5571378
tg4	Tg(Igh-V186.2-TCL1A)3Cro/0	involves: C3H * C57BL/6	MGI:3841692

Allelic Composition	Tg(Igh-ROR1)1Kip/0 Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic Background	B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro

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Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased chronic lymphocytic leukemia incidence ( J:206368 )

• develop leukemia at a younger median age than mice with either transgene alone

• expansion of CD5+B220^low B cells is accelerated and mice show earlier development of leukemia compared to single Tg(Igh-ROR1)1Kip mice

mortality/aging

premature death ( J:206368 )

• median survival is 50.6 weeks

hematopoietic system

enlarged spleen ( J:206368 )

increased lymphocyte cell number ( J:206368 )

• develop CD5+B220^low B-cell lymphocytosis at a younger median age than mice with either transgene alone

increased mature B cell number ( J:206368 )

• double mutants show an increase in percentage of CD5+B220^low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

immune system

enlarged spleen ( J:206368 )

increased lymphocyte cell number ( J:206368 )

• develop CD5+B220^low B-cell lymphocytosis at a younger median age than mice with either transgene alone

increased mature B cell number ( J:206368 )

• double mutants show an increase in percentage of CD5+B220^low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

growth/size/body

enlarged spleen ( J:206368 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:206368

Allelic Composition	Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0 Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic Background	involves: C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

increased B-1a cell number ( J:162077 )

• increased number of CD5+ B cells in spleen

immune system

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

increased B-1a cell number ( J:162077 )

• increased number of CD5+ B cells in spleen

neoplasm

increased chronic lymphocytic leukemia incidence ( J:162077 )

• a significant increased number of CD5+CD19+ and CD5+IgM+ B-cell populations compared with Tg(Igh-V186.2-TCL1A)3Cro mice alone

growth/size/body

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:162077

Allelic Composition	Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic Background	B6.Cg-Tg(Igh-V186.2-TCL1A)3Cro

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:206368 )

• median survival is 57.7 weeks

neoplasm

increased chronic lymphocytic leukemia incidence ( J:206368 )

• develop chronic lymphocytic leukemia-like disease

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:206368

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

peritoneal inflammation ( J:76574 )

• cellularity in the peritoneal cavity is increased 50- to 100- fold compared to controls due to presence of large B1b B-cell population

spleen hyperplasia ( J:76574 )

• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age

• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

abnormal B cell morphology ( J:76574 )

• an abnormal CD5⁺ CD11b⁺ population is found in all transgenic mice

• this B cell population makes up 44% of cells in the peritoneal cavity of 2-month old mice, 8.6% of splenocytes by 4 months of age, 43% of bone marrow cells by 8 months of age

increased marginal zone B cell number ( J:76574 )

• increased numbers of B cells are found in the marginal zone with a CD21^loCD5⁺ phenotype

neoplasm

increased leukemia incidence ( J:76574 )

• clonality of cells is observed in the CD5⁺ B cell population in mice over 7 months of age

• these cells have low proliferative activity, which is a characteristic of leukemia cells

• mice 13-18 months of age become visibly ill, have enlarged liver, spleens, and lymph nodes, and have white blood cell counts that are 50-fold higher than normal

• blood of these older mice contain large lymphoid cells, smeared cells, and lymphocytes with clumped nuclear chromatin

digestive/alimentary system

peritoneal inflammation ( J:76574 )

• cellularity in the peritoneal cavity is increased 50- to 100- fold compared to controls due to presence of large B1b B-cell population

liver/biliary system

enlarged liver ( J:76574 )

• livers are enlarged after the onset of leukemia

hematopoietic system

spleen hyperplasia ( J:76574 )

• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age

• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

abnormal B cell morphology ( J:76574 )

• an abnormal CD5⁺ CD11b⁺ population is found in all transgenic mice

• this B cell population makes up 44% of cells in the peritoneal cavity of 2-month old mice, 8.6% of splenocytes by 4 months of age, 43% of bone marrow cells by 8 months of age

increased marginal zone B cell number ( J:76574 )

• increased numbers of B cells are found in the marginal zone with a CD21^loCD5⁺ phenotype

growth/size/body

enlarged liver ( J:76574 )

• livers are enlarged after the onset of leukemia

spleen hyperplasia ( J:76574 )

• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age

• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:76574

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