Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  11
• Reference
  J:306895 Brown A, et al., The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function. Haematologica. 2020;105(2):317-324
• ID
  MGI:7314896

Genes

Gene	Assay Type
Rhdrox1	visible phenotype
Rhdrox2	visible phenotype
Pttg1	visible phenotype

Notes

• Experiment
  By generating and analyzing reciprocal congenic mice for this locus, the authors demonstrate that the Rhdrox1/Rhdrox2 region indeed determines the sensitivity of hematopoietic stem and progenitor cells to hydroxyurea.
  
  The authors verified pituitary tumor-transforming gene 1 (Pttg1; MGI:1353578) as the quantitative trait gene regulating the differential response of hematopoietic stem and progenitor cells to hydroxyurea treatment and which might therefore be linked to the regulation of lifespan.