Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  5
• Reference
  J:27407 Pathak BG, et al., Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl). Genomics. 1995 Jul 1;28(1):116-8
• ID
  MGI:45700

Genes

Gene	Assay Type	Description
Alb	reported elsewhere
Areg	Southern analysis	Areg cDNA1
Btc	Southern analysis	Btc cDNA1
Fgf5	reported elsewhere

Notes

• Reference
  Because the sequence and RFLV sizes are nearly identical and because Sdgf and Areg cosegregated in 183 mice, the authors suggest that Sdgf and Areg are species variants derived from the same gene.
• Experiment
  Offspring types indicate alleles inherited from F1 parent.
  

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b>/<s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b>/<b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  Copeland-Jenkins
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

CROSS Data

MC #mice	Alb	Areg	Btc	Fgf5
83	b	b	b	b
85	s	s	s	s
0	s	b	b	b
1	b	s	s	s
0	s	s	b	b
0	b	b	s	s
3	s	s	s	b
2	b	b	b	s

Additional Mice Typed Only for Specific Pairs of Loci

Marker 1	Marker 2	# Recombinants	# Parentals
Alb	Areg	0	17
Areg	Btc	0	2
Btc	Fgf5	0	4

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
Alb	Areg	1	191	0.524	0.522
Areg	Btc	0	176	0.000	0.000
Btc	Fgf5	5	178	2.809	1.238