Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:7838 Sala-Trepat JM, et al., A lethal deletion on mouse chromosome 7 affects regulation of liver-cell-specific functions: posttranscriptional control of serum protein and transcriptional control of aldolase B synthesis. Proc Natl Acad Sci U S A. 1985 Apr;82(8):2442-6
• ID
  MGI:43325

Genes

Gene	Allele
Tyr	Tyr^c-14CoS

Notes

• Experiment
  Normal and Tyr^c-14CoS/Tyr^c-14CoS albino deletion mice were examined for genes affecting liver function. Tyr^c-14CoS/Tyr^c-14CoS mice are deficient in serum albumin, alpha-fetoprotein, transferin, and aldolase B. Levels of mRNA for the genes Alb1, Afp and Trf were normal indicating that the deficiencies in these gene's products in Tyr^c-14CoS/Tyr^c-14CoS must occur posttranscriptionally. In contrast, levels of Aldo2 mRNA are severely reduced in Tyr^c-14CoS/Tyr^c-14CoS mice indicating control at the level of transcription or message stability. These results support the idea that genes related to control and regulation of liver cell differentiation are located in the albino region of Chromosome 7.