Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  2
• Reference
  J:912 Avraham KB, et al., Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4. Genomics. 1992 Jun;13(2):264-8
• ID
  MGI:40871

Genes

Gene	Assay Type	Description
Pax1	reported elsewhere	Siracusa, et al., Genomixcs 6:491-504, 1990
Foxa2	Southern analysis	HNF-3(beta)
Hck	reported elsewhere	Siracusa, et al., Genetics 122:669-679, 1989
Src	reported elsewhere	Siracusa, et al., Genetics 122:669-679, 1989
Ada	reported elsewhere	Siracusa, et al., Genetics 122:669-679, 1989
Hnf4a	Southern analysis	HNF-4

Notes

• Reference
  Revised gene symbols Hck, Hnf3a, Hnf3b, Hnf3g, Tcf-4 and Tpi-rs3 (formerly Hck-1, Tcf-3a Tcf-3b, Tcf-3g, Hnf-4 and Tpi-3 respectively).
• Experiment
  Data for 81 mice are presented. Up to 150 mice were analyzed for some pairs of markers producing the following statement of order and distance: centromere - Pax-1 - 3.1 +/- 1.5cM - Tcf-3b - 2.7 +/- 1.5cM - Hck - 4.0 +/- 1.6cM - Src - 2.7 +/- 1.3cM - (Ada, Tcf-4).Offspring types indicate alleles inherited from F1 parent.
  

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  Copeland-Jenkins
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

CROSS Data

MC #mice	Pax1	Foxa2	Hck	Src	Ada	Hnf4a
29	b	b	b	b	b	b
43	s	s	s	s	s	s
4	s	b	b	b	b	b
0	b	s	s	s	s	s
0	s	s	b	b	b	b
2	b	b	s	s	s	s
0	s	s	s	b	b	b
0	b	b	b	s	s	s
1	s	s	s	s	b	b
2	b	b	b	b	s	s

Additional Mice Typed Only for Specific Pairs of Loci

Marker 1	Marker 2	# Recombinants	# Parentals
Pax1	Foxa2	0	48
Foxa2	Hck	1	29
Hck	Src	6	63
Src	Ada	1	68
Ada	Hnf4a	0	37

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
Pax1	Foxa2	4	129	3.101	1.526
Foxa2	Hck	3	111	2.703	1.539
Hck	Src	6	150	4.000	1.600
Src	Ada	4	150	2.667	1.315
Ada	Hnf4a	0	118	0.000	0.000