Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:2947 Klebig ML, et al., Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1363-7
• ID
  MGI:40579

Genes

Gene	Allele	Assay Type	Description
Mesd		reported elsewhere
Fah		Southern analysis	RN273
D7Rn2		Southern analysis	RN226.1
Hsdr1		visible phenotype	lethality
Tyr	Tyr^c-14CoS	visible phenotype	coat color
D7Rn1		Southern analysis	RN207.2

Notes

• Reference
  Author used msd for mesd.
• Experiment
  The breakpoint-fusion fragment of the albino deletion Tyr^c-14Cos was cloned and the proximal breakpoint was shown to disrupt the Fah gene. Further, none of the albino deletions expressing the Hsdr1 mutant phenotype expressed Fah. These data map Fah within or proximal to Hsdr1 as defined by deletion breakpoints and disruption of the Fah gene and suggest Fah may be responsible for the Hsdr1 deletion phenotype. Breakpoint-fusion cloning of Tyr^c-14Cos identified two anonymous sequences defining the endsof the Tyr^c-14Cos deletion. D7Rn2 defines the proximal end of Tyr^c-14Cos and D7Rn1 the distal end. Southern analysis further refined the location of D7Rn2 to the region distal to mesd and proximal or within Hsdr1.