Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  10
• Reference
  J:10751 Huang E, et al., The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 1990 Oct 5;63(1):225-33
• ID
  MGI:40121

Genes

Gene	Allele	Assay Type	Description
Tg(MYC)1Led		Southern analysis	TIS Dra/Sal
Kitl	Kitl^Sl	Southern analysis	1.4 kb KL cDNA

Notes

• Experiment
  C57BL/6J congenic mice that carry the Chromosome 10 Sl locus from C3HeB/FeJ were intercrossed (C57BL/6J Sl^C3H/+ x Sl^C3H/+) and the progeny analzyed using Kitl and Tg.EB probes. Offspring segregated in accord for Sl and the Kitl and Tg.EB RFLVs from C3HeB/FeJ. Sl/Sl homozygotes did not hybridize to the Kitl probe indicating that the locus that encodes for Kitl is deleted in these mice. This supports the assertion that Kitl is a product of the Sl gene.