Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• ID
  MGI:3697870

Genes

Gene	Assay Type
Pbft2	visible phenotype
Mofp3	visible phenotype
Mofp6	visible phenotype
Gf2	visible phenotype
Gf4	visible phenotype
Rfpw3	visible phenotype
Rfpw4	visible phenotype
Rfpw7	visible phenotype
Cfd	reported elsewhere
Pmch	reported elsewhere
Plpp2	reported elsewhere
Gamt	reported elsewhere

Notes

• Experiment
  Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for the genome scan. Parental strain C57BL/6J displays decreased activity and increased body weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.
  
  Linkage to percent body fat, named Pbft2, mapped to 42 cM on mouse Chromosome 10 with LOD=5.83. Linkage to mesenteric and omental fat pad weight mapped to 40 cM (Mofp3, LOD=6.13) in both sexes and to 28 cM (Mofp6, LOD=3.71) in females only. Linkage to gonadal fat pad weight mapped to 42 cM in both sexes (Gf2, LOD=7.14) and also in males (Gf4, LOD=4.43). Linkage to retroperitoneal fat pad weight mapped to 42 cM in both sexes (Rfpw3,LOD=7.38) and in males (Rfpw4, LOD=3.66), and mapped to 4 cM (Rfpw7, LOD=4.55) in females. Potential candidate genes include Cfd (Adipsin, 43 cM), Pmch (47 cM), Ppap2c (42 cM), and Gamt (43 cM).