Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  3
• Reference
  J:109420 de Buhr MF, et al., Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics. 2006 May 16;25(3):426-34
• ID
  MGI:3641303

Genes

Gene	Assay Type
Cdcs1	reported elsewhere
Gbp2b	reported elsewhere
Adh1	reported elsewhere
Bglap2	reported elsewhere

Notes

• Experiment
  Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10^tm1Cgn and colitis resistant inbred strain C57BL/6J-Il10^tm1Cgn.
  
  Gbp2b (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10^tm1Cgn animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wildtype strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to5-fold, in C3H/HeJBir-Il10^tm1Cgnanimals.