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Mapping Data
  • Experiment
  • Chromosome
  • Reference
    J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
  • ID
GeneAlleleAssay TypeDescription
Lbn4 visible phenotype
D5Mit32 PCR
Tbx5 reported elsewhere
Dtx2 reported elsewhere
Fzd9 reported elsewhere
Fzd10 reported elsewhere
Zfp11 reported elsewhere
Eln reported elsewhere
Epo reported elsewhere
Fbxo24 reported elsewhere
Taf6 reported elsewhere
  • Experiment
    Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

    On mouse Chromosome 5, linkage to humerus length in males mapped to 78 cM near D5Mit32 (LPR=2.6). This locus is named Lbn4 (long bones 4). The confidence interval spans 90 cM - 130 cM. Potential candidate genes mapping near Lbn4 include Tbx5 (65 cM), Dtx2, Fzd9 (75 cM), Fzd10, Zfp11, Eln (75 cM), Epo (78 cM), Fbxo24, and Taf6.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
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