Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  5
• Reference
  J:92107 Seedorf H, et al., Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21). J Dent Res. 2004 Aug;83(8):608-12
• ID
  MGI:3586639

Genes

Gene	Assay Type
Enam	visible phenotype
D5Mit18	PCR
D5Mit10	PCR
Ambn	reported elsewhere
Csn	reported elsewhere
Pad5	reported elsewhere
Tnrc18	reported elsewhere
Csn3	reported elsewhere
mc	reported elsewhere
Mtv32	reported elsewhere
Odc-rs21	reported elsewhere
Afp	reported elsewhere
Alb	reported elsewhere
Btc	reported elsewhere
Areg	reported elsewhere
Art3	reported elsewhere
Shroom3	reported elsewhere
Anxa3	reported elsewhere
Wdfy3	reported elsewhere

Notes

• Experiment
  The abte mutation was created by ENU mutagenesis of male C3HeB/FeJ animals, and the locus was mapped using an out-cross/backcross scheme with C57BL/6J animals. The abte (abnormal tooth enamel) locus mapped to a 9 cM interval on mouse Chromosome 5 betweenD5Mit18 (45 cM) and D5Mit10 (54 cM). A strong candidate gene mapping to the abte interval is Ambn at 46 cM. A nonsense mutation in human AMBN is associated with the locus for autosomal dominant amelogenesis imperfecta on 4p21 in humans. Other potential candidate genes mapping to this region are Csn (45 cM), Pad5 (45 cM), Zfp469, Csn3 (45.2 cM), mc (48 cM), Mtv32 (48 cM), Odc-rs21 (48 cM), Afp (50 cM), Alb1 (50 cM), Btc (51 cM), Areg (51 cM), Art3 (52 cM), Shroom3 (52 cM), Anxa3 (54 cM), and Wdfy3 (54 cM).